Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD.

Acetates / pharmacokinetics Acetylcholinesterase / metabolism Aged Aged, 80 and over Alzheimer Disease / diagnosis Cognitive Dysfunction / diagnostic imaging Female Fluorodeoxyglucose F18 / pharmacokinetics Humans Male Middle Aged Piperidines / pharmacokinetics Positron-Emission Tomography Radiopharmaceuticals / pharmacokinetics
Acetylcholinesterase Alzheimer's disease FDG MP4A

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2019
Historique:
received: 08 02 2019
revised: 24 07 2019
accepted: 08 08 2019
pubmed: 20 8 2019
medline: 22 9 2020
entrez: 19 8 2019
Statut: ppublish

Résumé

Elucidating the relationship between neuronal metabolism and the integrity of the cholinergic system is prerequisite for a profound understanding of cholinergic dysfunction in Alzheimer's disease. The cholinergic system can be investigated specifically using positron emission tomography (PET) with [

Identifiants

DOI: 10.1016/j.nicl.2019.101978 PMID: 31422337 PMC: PMC6706587
pubmed: 31422337
pii: S2213-1582(19)30328-6
doi: 10.1016/j.nicl.2019.101978
pmc: PMC6706587
pii:
doi:

Substances chimiques

Acetates 0
N-methyl-4-piperidyl acetate 0
Piperidines 0
Radiopharmaceuticals 0
Fluorodeoxyglucose F18 0Z5B2CJX4D
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101978

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Références

Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Sci Transl Med. 2011 Nov 30;3(111):111cm33
pubmed: 22133718
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Curr Geriatr Rep. 2018 Mar;7(1):1-11
pubmed: 29503795
Alzheimers Res Ther. 2014 Jul 03;6(4):37
pubmed: 25024750
Stud Health Technol Inform. 2000;77:195-9
pubmed: 11187541
Neurobiol Aging. 2012 May;33(5):867-77
pubmed: 20961662
Rinsho Shinkeigaku. 1984 Nov;24(11):1128-35
pubmed: 6518703
J Nucl Med. 1995 Jul;36(7):1238-48
pubmed: 7790950
Eur J Nucl Med Mol Imaging. 2017 Dec;44(13):2249-2256
pubmed: 29026951
N Engl J Med. 2012 Aug 30;367(9):795-804
pubmed: 22784036
Hum Brain Mapp. 2002 Jan;15(1):1-25
pubmed: 11747097
Acta Neuropathol. 2015 Apr;129(4):527-40
pubmed: 25633602
Biochim Biophys Acta. 2012 Mar;1822(3):380-5
pubmed: 22115832
Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):613-20
pubmed: 22270508
Brain. 2018 Jun 1;141(6):1840-1854
pubmed: 29672680
Cell Rep. 2018 Jul 3;24(1):38-46
pubmed: 29972789
BMC Nucl Med. 2006 Jul 12;6:4
pubmed: 16836759
J Nucl Med. 2011 Feb;52(2):173-9
pubmed: 21233181
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
J Cereb Blood Flow Metab. 2010 Jan;30(1):2-14
pubmed: 19738630
Nuklearmedizin. 2011;50(2):74-82
pubmed: 21286660
Neuroimage Clin. 2016 Oct 08;14:77-86
pubmed: 28138429
Neuroimage Clin. 2014 Nov 18;7:34-42
pubmed: 25610765
Eur J Nucl Med. 1999 Feb;26(2):135-43
pubmed: 9933347
Dement Geriatr Cogn Disord. 1998;9 Suppl 2:20-6
pubmed: 9718231
J Cereb Blood Flow Metab. 2017 Feb;37(2):740-749
pubmed: 27107028
Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1700-9
pubmed: 27026271
Brain. 2018 Jul 1;141(7):1917-1933
pubmed: 29850777
Med Image Anal. 2001 Jun;5(2):143-56
pubmed: 11516708
J Neurochem. 1987 Jun;48(6):1845-50
pubmed: 3572402
Eur J Nucl Med Mol Imaging. 2017 Nov;44(12):2073-2083
pubmed: 28785843
Brain. 2018 Mar 1;141(3):903-915
pubmed: 29309600
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Neurobiol Aging. 2017 May;53:27-35
pubmed: 28208063
Nat Commun. 2016 Nov 04;7:13249
pubmed: 27811848
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322
pubmed: 11545704
Alzheimer Dis Assoc Disord. 1995 Spring;9(1):6-16
pubmed: 7605624
Mol Psychiatry. 2017 Nov;22(11):1531-1538
pubmed: 28894304
Ann Neurol. 1997 Jul;42(1):85-94
pubmed: 9225689
Pharmacol Res. 2018 Apr;130:331-365
pubmed: 29458203
Neurology. 2012 May 15;78(20):1576-82
pubmed: 22551733
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Cereb Cortex. 2016 Jun;26(6):2411-2426
pubmed: 25840425
Schizophr Res. 2006 Apr;83(2-3):155-71
pubmed: 16448806
Lancet Neurol. 2015 Oct;14(10):1037-53
pubmed: 26318837
Alzheimer Dis Assoc Disord. 2000;14 Suppl 1:S114-8
pubmed: 10850739
Eur J Nucl Med. 1994 Oct;21(10):1052-60
pubmed: 7828614
Eur J Nucl Med Mol Imaging. 2016 Mar;43(3):526-36
pubmed: 26555082
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
J Neural Transm (Vienna). 2000;107(12):1457-68
pubmed: 11458998
Neuroimage. 2004;23 Suppl 1:S69-84
pubmed: 15501102

Auteurs

Nils Richter (N)

Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany; Max-Planck-Institute for Metabolism Research, 50937 Cologne, Germany. Electronic address: n.richter@fz-juelich.de.

Nils Nellessen (N)

Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany.

Julian Dronse (J)

Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany.

Kim Dillen (K)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany.

Heidi I L Jacobs (HIL)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States of America; The Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States of America; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands.

Karl-Josef Langen (KJ)

Medical Imaging Physics (INM-4), Institute of Neuroscience and Medicine (INM-4), Research Center Jülich, 52425 Jülich, Germany.

Markus Dietlein (M)

Department of Nuclear Medicine, University Hospital Cologne, 50937 Cologne, Germany.

Lutz Kracht (L)

Max-Planck-Institute for Metabolism Research, 50937 Cologne, Germany; Department of Nuclear Medicine, University Hospital Cologne, 50937 Cologne, Germany.

Bernd Neumaier (B)

Institute for Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, 50937 Cologne, Germany; Nuclear Chemistry, Institute of Neuroscience and Medicine (INM-5), Research Center Jülich, 52425 Jülich, Germany.

Gereon R Fink (GR)

Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany.

Juraj Kukolja (J)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany; Department of Neurology and Neurophysiology, Helios University Hospital Wuppertal, 42283 Wuppertal, Germany.

Oezguer A Onur (OA)

Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, 52425 Jülich, Germany.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Spatial distributions of cholinergic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Spatial distributions of cholinergic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Spatial distributions of cholinergic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Spatial distributions of cholinergic...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Spatial distributions of cholinergic...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Spatial distributions of cholinergic...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Fluorodésoxyglucose F18 › Spatial distributions of cholinergic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatial distributions of cholinergic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Spatial distributions of cholinergic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Spatial distributions of cholinergic...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Spatial distributions of cholinergic...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Spatial distributions of cholinergic...