Bacterial Amyloids: The Link between Bacterial Infections and Autoimmunity.
SLE
amyloid
autoimmune response
biofilm
curli
infection
lupus
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
22
04
2019
revised:
19
06
2019
accepted:
03
07
2019
pubmed:
20
8
2019
medline:
1
7
2020
entrez:
20
8
2019
Statut:
ppublish
Résumé
Molecular mimicry is a common mechanism used by many bacteria to evade immune responses. In recent years, it has become evident that bacteria also decorate the extracellular matrix (ECM) of their biofilms with molecules that resemble those of the host. These molecules include amyloids and other proteins, polysaccharides, and extracellular DNA. Bacterial amyloids, like curli, and extracellular DNA are found in the biofilms of many species. Recent work demonstrated that curli and DNA form unique molecular structures that are recognized by the immune system, causing activation of autoimmune pathways. Although a variety of mechanisms have been suggested as the means by which infections initiate and/or exacerbate autoimmune diseases, the mechanism remains unknown. In this article, we discuss recent work on biofilms that highlight the role of amyloids as a carrier for DNA and potentiator of autoimmune responses, and we propose a novel link between bacterial infections and autoimmune diseases.
Identifiants
pubmed: 31422877
pii: S0966-842X(19)30183-0
doi: 10.1016/j.tim.2019.07.002
pmc: PMC6800627
mid: NIHMS1534206
pii:
doi:
Substances chimiques
Amyloid
0
Bacterial Proteins
0
DNA, Bacterial
0
Crl protein, Bacteria
148349-72-8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
954-963Subventions
Organisme : NIAID NIH HHS
ID : R21 AI137541
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI132996
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI125429
Pays : United States
Organisme : NIAMS NIH HHS
ID : R56 AR072115
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI126133
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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