Association of Low Maternal Pregnancy-associated Plasma Protein A with Adverse Perinatal Outcome.
adverse perinatal outcome
down syndrome
iugr
papp-a
preeclampsia
stillbirth
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
17 Jun 2019
17 Jun 2019
Historique:
entrez:
20
8
2019
pubmed:
20
8
2019
medline:
20
8
2019
Statut:
epublish
Résumé
The aim is to provide an overall view of the association of low pregnancy-associated plasma protein A (PAPP-A) levels with adverse perinatal outcomes. The available literature in PubMed/Medline regarding PAPP-A and adverse pregnancy outcomes was searched for related articles, including terms such as "PAPP-A," "intrauterine growth restriction (IUGR)," "small for gestational age (SGA)," "stillbirth," "adverse outcome," and others. The fifth percentile is supported by many recent studies to be PAPP-A's cutoff for adverse outcome detection and the increased risk seems to be extremely high below 0.2 PAPP-A MoM (multiple of the median). Apart from chromosomal abnormalities, preeclampsia, intrauterine fetal demise, and pregnancy loss have been associated with maternal serum PAPP-A. For results below the first centile, PAPP-A has a strong positive predictive value for SGA and IUGR. Except for its vital role on the cleavage of insulin-like growth factor binding proteins (IGFBP), PAPP-A has proven to be a reliable marker for prenatal screening. Even though PAPP-A as a single predictor proved to be valuable for the prediction of some adverse perinatal outcomes, in some cases, a combination of PAPP-A to other maternal serum markers led to an increase in detection rates. PAPP-A is a promising maternal serum marker for pregnancy outcome prediction with more studies needed in order for its potentials to be fully understood and exploited.
Identifiants
pubmed: 31423389
doi: 10.7759/cureus.4912
pmc: PMC6692091
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e4912Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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