Bone alterations in inflammatory bowel diseases.
Bone alterations
Bone mineral density
Crohn’s disease
Inflammatory bowel diseases
Osteopenia
Osteoporosis
Ulcerative colitis
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
06 Aug 2019
06 Aug 2019
Historique:
received:
20
03
2019
revised:
14
06
2019
accepted:
26
06
2019
entrez:
20
8
2019
pubmed:
20
8
2019
medline:
20
8
2019
Statut:
ppublish
Résumé
Inflammatory bowel diseases (IBDs) are characterized by a multifactorial partially unknown etiology that involves genetic, immunological and environmental factors. Up to 50% of IBD patients experience at least one extraintestinal manifestation; among them is the involvement of bone density which is referred to as metabolic bone disease (MBD), including osteopenia and osteoporosis. Bone alterations in IBDs population appear to have a multifactorial etiology: Decreased physical activity, inflammation-related bone resorption, multiple intestinal resections, dietary malabsorption of minerals and vitamin D deficiency, genetic factors, gut-bone immune signaling interaction, steroid treatment, microbiota and pathogenic micro-organisms interaction, and dietary malabsorption of minerals, that, all together or individually, may contribute to the alteration of bone mineral density. This review aims to summarize the prevalence and pathophysiology of metabolic bone alterations in IBD subjects outlining the main risk factors of bone fragility. We also want to underline the role of the screening and prophylaxis of bone alterations in Crohn's disease and ulcerative colitis patients and the importance of treating appropriately MBD.
Identifiants
pubmed: 31423424
doi: 10.12998/wjcc.v7.i15.1908
pmc: PMC6695530
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1908-1925Déclaration de conflit d'intérêts
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
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