Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood.
Journal
Journal of speech, language, and hearing research : JSLHR
ISSN: 1558-9102
Titre abrégé: J Speech Lang Hear Res
Pays: United States
ID NLM: 9705610
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
pubmed:
20
8
2019
medline:
21
10
2020
entrez:
20
8
2019
Statut:
ppublish
Résumé
Purpose Children with poor language tend to have worse psychosocial outcomes compared to their typically developing peers. The most common explanations for such adversities focus on developmental psychological processes whereby poor language triggers psychosocial difficulties. Here, we investigate the possibility of shared biological effects by considering whether the same genetic variants, which are thought to influence language development, are also predictors of elevated psychosocial difficulties during childhood. Method Using data from the U.K.-based Avon Longitudinal Study of Parents and Children, we created a number of multi-single-nucleotide polymorphism polygenic profile scores, based on language and reading candidate genes (
Identifiants
pubmed: 31425657
doi: 10.1044/2019_JSLHR-L-19-0001
pmc: PMC6808346
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3381-3396Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Références
Pediatrics. 2010 Dec;126(6):e1530-7
pubmed: 21059719
Am J Hum Genet. 2009 Aug;85(2):264-72
pubmed: 19646677
Biol Psychiatry. 2011 Aug 1;70(3):237-45
pubmed: 21457949
Science. 2018 Jun 22;360(6395):
pubmed: 29930110
J Child Lang. 1989 Jun;16(2):239-49
pubmed: 2760125
J Am Acad Child Adolesc Psychiatry. 2001 Jan;40(1):75-82
pubmed: 11195567
J Speech Lang Hear Res. 2004 Feb;47(1):145-61
pubmed: 15072535
Biodemography Soc Biol. 2014;60(2):199-211
pubmed: 25343367
Int J Lang Commun Disord. 2015 May-Jun;50(3):358-73
pubmed: 25556640
Nat Genet. 2019 Mar;51(3):431-444
pubmed: 30804558
Bioinformatics. 2015 May 1;31(9):1466-8
pubmed: 25550326
Matrix Biol. 2017 Jul;60-61:16-26
pubmed: 27771416
J Child Psychol Psychiatry. 1998 Sep;39(6):879-91
pubmed: 9758196
Front Mol Neurosci. 2017 Mar 23;10:83
pubmed: 28386217
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Transl Psychiatry. 2017 Dec 18;7(12):1296
pubmed: 29249811
Am J Psychiatry. 2019 May 1;176(5):376-387
pubmed: 30845820
PLoS Genet. 2013 Mar;9(3):e1003348
pubmed: 23555274
Nat Commun. 2018 Oct 4;9(1):4079
pubmed: 30287866
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Memory. 1994 Jun;2(2):103-27
pubmed: 7584287
Lang Speech Hear Serv Sch. 2012 Oct;43(4):445-60
pubmed: 22826367
J Speech Lang Hear Res. 1998 Jun;41(3):688-700
pubmed: 9638932
J Child Psychol Psychiatry. 2016 Nov;57(11):1247-1257
pubmed: 27184709
J Speech Lang Hear Res. 2017 Jun 10;60(6):1635-1647
pubmed: 28586830
J Child Psychol Psychiatry. 2017 Oct;58(10):1068-1080
pubmed: 28369935
Eur J Hum Genet. 2015 Oct;23(10):1370-7
pubmed: 25585696
J Speech Lang Hear Res. 1997 Dec;40(6):1245-60
pubmed: 9430746
Transl Psychiatry. 2019 Feb 11;9(1):77
pubmed: 30741946
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Mol Psychiatry. 2018 May;23(5):1368-1374
pubmed: 28785111
J Neurodev Disord. 2009 Dec;1(4):264-82
pubmed: 19997522
Biol Psychiatry. 2017 Nov 15;82(10):702-708
pubmed: 28823710
J Child Psychol Psychiatry. 2014 May;55(5):516-27
pubmed: 24410167
J Child Psychol Psychiatry. 1997 Jul;38(5):581-6
pubmed: 9255702
Br J Dev Psychol. 2016 Nov;34(4):538-554
pubmed: 27226087
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11727-11732
pubmed: 29078306
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
J Child Psychol Psychiatry. 2014 Oct;55(10):1068-87
pubmed: 25132410
J Abnorm Child Psychol. 2015 Nov;43(8):1515-1527
pubmed: 26105208
Behav Genet. 2011 Jan;41(1):90-104
pubmed: 21165691
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Child Dev. 2007 Sep-Oct;78(5):1441-57
pubmed: 17883441
PLoS One. 2016 Jul 12;11(7):e0156678
pubmed: 27404489
Res Dev Disabil. 2017 Mar;62:148-159
pubmed: 28167313
Science. 2013 Jun 21;340(6139):1467-71
pubmed: 23722424
Eur Child Adolesc Psychiatry. 2019 Jul;28(7):993-1004
pubmed: 30519863
Child Dev. 2005 Jul-Aug;76(4):856-68
pubmed: 16026501
Mol Psychiatry. 2019 Feb 13;:null
pubmed: 30760887