Toward the formation of neural circuits in human brain organoids.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
13
05
2019
revised:
08
07
2019
accepted:
12
07
2019
pubmed:
20
8
2019
medline:
15
4
2020
entrez:
20
8
2019
Statut:
ppublish
Résumé
Because of the ability to recapitulate normal developmental processes, brain organoids derived from pluripotent stem cells are an important experimental resource to investigate the development and pathogenesis of human brains. Although brain organoids are used in research on diseases such as microcephaly, it has traditionally been difficult to analyze diseases that affect neuronal networks between distant brain regions, as effective brain organoids containing multiple brain regions with defined connectivity have yet to be established. In this review, we discuss strategies to construct such organoids and provide a review on recent progress on brain organoids.
Identifiants
pubmed: 31425932
pii: S0955-0674(19)30051-1
doi: 10.1016/j.ceb.2019.07.010
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-91Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.