A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin.
Animals
Binding Sites
Calcium
/ chemistry
Calcium Channels
/ chemistry
Collagen
/ chemistry
Drug Combinations
Endothelial Cells
/ cytology
Flavanones
/ chemistry
Humans
Laminin
/ chemistry
Mice
Molecular Docking Simulation
Patch-Clamp Techniques
Plant Proteins
/ antagonists & inhibitors
Plants
/ metabolism
Proteoglycans
/ chemistry
Animal lysosome
Fluorescence
Molecular docking
Patch-clamp
Plant vacuole
TPC channels
Journal
Biophysical chemistry
ISSN: 1873-4200
Titre abrégé: Biophys Chem
Pays: Netherlands
ID NLM: 0403171
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
29
06
2019
revised:
03
08
2019
accepted:
03
08
2019
pubmed:
20
8
2019
medline:
18
12
2019
entrez:
20
8
2019
Statut:
ppublish
Résumé
The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.
Identifiants
pubmed: 31426023
pii: S0301-4622(19)30292-3
doi: 10.1016/j.bpc.2019.106246
pii:
doi:
Substances chimiques
Calcium Channels
0
Drug Combinations
0
Flavanones
0
Laminin
0
Plant Proteins
0
Proteoglycans
0
matrigel
119978-18-6
Collagen
9007-34-5
naringenin
HN5425SBF2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106246Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.