Patients with Heart Failure and Preserved Ejection Fraction Are at Risk of Gastrointestinal Bleeding.
bleeding
heart failure
hemodynamics
oral anticoagulation
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
17 Aug 2019
17 Aug 2019
Historique:
received:
14
07
2019
revised:
11
08
2019
accepted:
14
08
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
21
8
2019
Statut:
epublish
Résumé
Two thirds of patients with heart failure and preserved ejection fraction (HFpEF) have an indication for oral anticoagulation (OAC) to prevent thromboembolic events. However, evidence regarding the safety of OAC in HFpEF is limited. Therefore, our aim was to describe bleeding events and to find predictors of bleeding in a large HFpEF cohort. We recorded bleeding events in a prospective HFpEF cohort. Out of 328 patients (median age 71 years (interquartile range (IQR) 67-77)), 64.6% ( OAC-treated HFpEF patients are at high risk of GI bleeding. High mRAP as an indicator of advanced stage of disease was predictive for GI bleeding events and provided additional risk stratification information beyond that obtained by HAS-BLED score.
Identifiants
pubmed: 31426462
pii: jcm8081240
doi: 10.3390/jcm8081240
pmc: PMC6724012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Daiichi Sankyo Company
ID : FA714B4101
Références
J Heart Valve Dis. 2004 Sep;13(5):701-12
pubmed: 15473466
Am Heart J. 2005 Apr;149(4):650-6
pubmed: 15990748
J Am Soc Echocardiogr. 2005 Dec;18(12):1440-63
pubmed: 16376782
Ann Intern Med. 2007 Jun 19;146(12):857-67
pubmed: 17577005
J Am Coll Cardiol. 2009 Mar 31;53(13):1119-26
pubmed: 19324256
N Engl J Med. 2009 Sep 17;361(12):1139-51
pubmed: 19717844
Ann Intern Med. 2009 Sep 1;151(5):297-305
pubmed: 19721017
Chest. 2010 Feb;137(2):263-72
pubmed: 19762550
J Thromb Haemost. 2010 Jan;8(1):202-4
pubmed: 19878532
Chest. 2010 Nov;138(5):1093-100
pubmed: 20299623
N Engl J Med. 2011 Sep 8;365(10):883-91
pubmed: 21830957
N Engl J Med. 2011 Sep 15;365(11):981-92
pubmed: 21870978
Eur Heart J. 2012 Jun;33(12):1500-10
pubmed: 22246443
Eur Heart J. 2013 May;34(19):1424-31
pubmed: 23470495
J Am Coll Cardiol. 2013 Oct 15;62(16):e147-239
pubmed: 23747642
Eur Heart J. 2013 Oct;34(39):3035-87
pubmed: 23996285
Circ Cardiovasc Imaging. 2013 Nov;6(6):1056-65
pubmed: 24036385
N Engl J Med. 2013 Nov 28;369(22):2093-104
pubmed: 24251359
Int J Cardiol. 2016 Jan 15;203:660-6
pubmed: 26580351
Eur J Heart Fail. 2016 Aug;18(8):891-975
pubmed: 27207191
J Am Coll Cardiol. 2016 Jul 12;68(2):189-99
pubmed: 27386773
Lancet. 2016 Aug 20;388(10046):761-75
pubmed: 27431356
Eur Heart J. 2016 Oct 7;37(38):2893-2962
pubmed: 27567408
Int J Cardiol. 2017 Feb 1;228:422-426
pubmed: 27870971
Clin Mol Hepatol. 2017 Mar;23(1):13-21
pubmed: 28288507
Eur Heart J. 2018 Sep 1;39(33):3021-3104
pubmed: 30165516
Thromb Haemost. 2018 Dec;118(12):2171-2187
pubmed: 30376678
Am J Cardiol. 2019 May 15;123(10):1649-1653
pubmed: 30928033