Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis.
Rhinocladiella mackenziei
antifungal therapy
cerebral phaeohyphomycosis
invasive fungal infections
plasma drug levels
therapeutic drug monitoring
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
09
06
2019
accepted:
15
07
2019
pubmed:
21
8
2019
medline:
7
8
2020
entrez:
21
8
2019
Statut:
epublish
Résumé
Posaconazole diffusion has been documented in various organs, which contrasts with the scarce data available for the human central nervous system (CNS). We analyzed posaconazole concentrations in plasma and multiple CNS specimens taken from a patient who received posaconazole because of cerebral phaeohyphomycosis. Low posaconazole concentrations were obtained in CNS specimens, with sample-to-plasma ratios between 5% and 22%. This case highlights the role of neurosurgery during cerebral phaeohyphomycoses, even those caused by posaconazole-susceptible black fungi.
Identifiants
pubmed: 31427294
pii: AAC.01184-19
doi: 10.1128/AAC.01184-19
pmc: PMC6811437
pii:
doi:
Substances chimiques
Antifungal Agents
0
Triazoles
0
posaconazole
6TK1G07BHZ
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
N Engl J Med. 2007 Jan 25;356(4):348-59
pubmed: 17251531
Clin Microbiol Rev. 2014 Jan;27(1):68-88
pubmed: 24396137
Clin Infect Dis. 2007 Jan 1;44(1):2-12
pubmed: 17143808
Expert Opin Drug Metab Toxicol. 2018 Aug;14(8):803-815
pubmed: 29943650
J Clin Microbiol. 2010 Sep;48(9):3451-4
pubmed: 20592148
J Antimicrob Chemother. 2008 Dec;62(6):1468-70
pubmed: 18824458
Antimicrob Agents Chemother. 2014 Aug;58(8):4941-3
pubmed: 24890587
J Antimicrob Chemother. 2005 Oct;56(4):745-55
pubmed: 16135526
Clin Infect Dis. 2011 Dec;53(11):1060-6
pubmed: 22045955
Antimicrob Agents Chemother. 1998 Jul;42(7):1738-44
pubmed: 9661014
Bone Marrow Transplant. 2009 Aug;44(4):269-70
pubmed: 19219077
Med Mycol. 2005 Feb;43(1):91-5
pubmed: 15712614
Antimicrob Agents Chemother. 2010 Feb;54(2):919-23
pubmed: 20008773