Early Life Stress, Physiology, and Genetics: A Review.

early life stress epigenetics genetics hypothalamic-pituitary-adrenal axis inflammation sympathetic nervous system

Journal

Frontiers in psychology
ISSN: 1664-1078
Titre abrégé: Front Psychol
Pays: Switzerland
ID NLM: 101550902

Informations de publication

Date de publication:
2019
Historique:
received: 23 12 2018
accepted: 02 07 2019
entrez: 21 8 2019
pubmed: 21 8 2019
medline: 21 8 2019
Statut: epublish

Résumé

Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS-health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS.

Identifiants

pubmed: 31428006
doi: 10.3389/fpsyg.2019.01668
pmc: PMC6688564
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1668

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Auteurs

Nia Fogelman (N)

Department of Psychology, Stony Brook University, Stony Brook, NY, United States.

Turhan Canli (T)

Department of Psychology, Stony Brook University, Stony Brook, NY, United States.

Classifications MeSH