Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis.
fibroblast-like synoviocytes
glucose metabolism
glycolytic inhibitors
hexokinase-2
rheumatoid arthritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
05
2019
accepted:
10
07
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like synoviocytes (FLS) phenotype and might contribute to early stage disease pathogenesis. RA FLS are transformed from quiescent to aggressive and metabolically active cells and several works have shown that glucose metabolism is increased in activated FLS. Glycolytic inhibitors reduce not only FLS aggressive phenotype
Identifiants
pubmed: 31428089
doi: 10.3389/fimmu.2019.01743
pmc: PMC6688519
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1743Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR073324
Pays : United States
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