Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice.
Anemia, Sickle Cell
/ genetics
Animals
Catalase
/ metabolism
Citrate (si)-Synthase
/ metabolism
Mice
Mice, Transgenic
Muscle, Skeletal
/ metabolism
NADPH Oxidases
/ metabolism
Oxidative Stress
Oxygen Consumption
Physical Conditioning, Animal
Superoxide Dismutase
/ metabolism
Up-Regulation
Xanthine Oxidase
/ metabolism
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
11
2018
revised:
01
03
2019
accepted:
23
06
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
4
1
2020
Statut:
epublish
Résumé
Oxidative stress is a key feature in the pathophysiology of sickle cell disease. Endurance training has been shown to reduce oxidative stress in the heart and the liver of sickle mice. However, the effects of endurance training on skeletal muscles, which are major producers of reactive oxygen species during exercise, are currently unknown. The aim of this study was to evaluate the effect of sickle genotype on prooxidant/antioxidant response to individualized endurance training in skeletal muscles of sickle mice. Healthy and homozygous Townes sickle mice were divided into trained or sedentary groups. Maximal aerobic speed and V̇O
Identifiants
pubmed: 31428225
doi: 10.1155/2019/3765643
pmc: PMC6681588
doi:
Substances chimiques
Catalase
EC 1.11.1.6
Superoxide Dismutase
EC 1.15.1.1
Xanthine Oxidase
EC 1.17.3.2
NADPH Oxidases
EC 1.6.3.-
Citrate (si)-Synthase
EC 2.3.3.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3765643Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL106192
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL117721
Pays : United States
Déclaration de conflit d'intérêts
The authors have no competing interests, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included in this manuscript.
Références
Mol Cell Biochem. 2000 Jul;210(1-2):23-8
pubmed: 10976754
J Appl Physiol (1985). 2002 Oct;93(4):1301-9
pubmed: 12235029
Clin Exp Pharmacol Physiol. 2003 Jan-Feb;30(1-2):77-81
pubmed: 12542458
Crit Care. 2004 Oct;8(5):331-6
pubmed: 15469594
Gen Physiol Biophys. 2004 Sep;23(3):265-95
pubmed: 15638116
Eur J Clin Nutr. 2006 Dec;60(12):1345-54
pubmed: 16788711
Physiol Rev. 2008 Oct;88(4):1243-76
pubmed: 18923182
Eur J Appl Physiol. 2009 Apr;105(6):843-50
pubmed: 19125280
Drug Chem Toxicol. 2009;32(4):438-42
pubmed: 19793038
Exp Biol Med (Maywood). 2010 Apr;235(4):497-505
pubmed: 20407082
Med Sci Sports Exerc. 2011 Jun;43(6):1017-24
pubmed: 21085043
Lancet. 2010 Dec 11;376(9757):2018-31
pubmed: 21131035
PLoS One. 2012;7(4):e35273
pubmed: 22530000
J Physiol. 2012 Jul 15;590(14):3349-60
pubmed: 22586215
Free Radic Res. 2014 Jan;48(1):12-29
pubmed: 23915064
Br J Haematol. 2015 Mar;168(5):747-56
pubmed: 25382268
Am J Pathol. 2015 May;185(5):1448-56
pubmed: 25773175
Biomolecules. 2015 Apr 10;5(2):356-77
pubmed: 25866921
Sports Med. 2016 May;46(5):629-39
pubmed: 26666745
Br J Sports Med. 2018 Feb;52(4):214-218
pubmed: 26701924
Free Radic Biol Med. 2016 Sep;98:13-17
pubmed: 26912036
J Physiol. 2016 Sep 15;594(18):5195-207
pubmed: 27094017
Blood Cells Mol Dis. 2016 Nov;62:13-21
pubmed: 27835777
Blood Cells Mol Dis. 2017 Mar;63:37-44
pubmed: 28110136
J Clin Invest. 2017 Mar 1;127(3):750-760
pubmed: 28248201
J Appl Physiol (1985). 2017 May 1;122(5):1362-1369
pubmed: 28280108
Blood Cells Mol Dis. 2018 Mar;69:45-52
pubmed: 28624257
Sleep. 2017 Aug 1;40(8):
pubmed: 28633495
Mol Genet Metab. 2018 Mar;123(3):400-410
pubmed: 29307759
J Pediatr Hematol Oncol. 2018 Jul;40(5):348-354
pubmed: 29621064
Lancet Haematol. 2018 Nov;5(11):e554-e562
pubmed: 30389037
Anal Biochem. 1988 Oct;174(1):331-6
pubmed: 3064653
Anal Biochem. 1971 Nov;44(1):276-87
pubmed: 4943714
J Lab Clin Med. 1967 Jul;70(1):158-69
pubmed: 6066618
Methods Enzymol. 1984;105:457-64
pubmed: 6547201
Am J Physiol. 1994 Feb;266(2 Pt 2):R375-80
pubmed: 8141392
J Exp Biol. 1996 Apr;199(Pt 4):801-14
pubmed: 8788087
Science. 1997 Oct 31;278(5339):873-6
pubmed: 9346487