Assessment of serum thyroid hormone autoantibodies in the first trimester of gestation as predictors of postpartum thyroiditis.
DM-1, type 1 diabetes mellitus
FNAB, fine-needle aspiration biopsy
FT3, free triiodothyronine
FT4, free thyroxine
GD, Graves’ disease
HT, Hashimoto’s thyroiditis
L-T4, Levothyroxine
PH, permanent hypothyroidism
PPT, Postpartum thyroiditis
Postpartum
Postpartum thyroiditis
Pregnancy
THAb, thyroid hormone autoantibodies
TPOAb, thyroperoxidase autoantibodies
TSH, thyrotropin
Tg, thyroglobulin
TgAb, thyroglobulin autoantibodies
Thyroid autoimmunity
Thyroid hormone autoantibodies
US, ultrasound
UST, ultrasonography signs suggestive of thyroiditis
Journal
Journal of clinical & translational endocrinology
ISSN: 2214-6237
Titre abrégé: J Clin Transl Endocrinol
Pays: Netherlands
ID NLM: 101629335
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
21
06
2019
revised:
22
07
2019
accepted:
22
07
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
21
8
2019
Statut:
epublish
Résumé
Measurement of serum thyroperoxidase autoantibodies (TPOAb) during gestation as a classical marker for the risk of postpartum thyroiditis (PPT) predicts PPT in 1/3 to 1/2 of women. Very few studies have measured serum thyroid hormone Ab (THAb) during gestation, and none as a possible marker for PPT. In 412 women who were followed up from 7 to 11 weeks of gestation through 12 months after delivery, we measured THAb (T3.IgM, T3.IgG, T4.IgM, T4.IgG), thyroglobulin autoantibodies (TgAb) and TPOAb at study entry (7-11 week of gestation). Sixty-three women (15.3%) developed PPT, which progressed to permanent hypothyroidism (PH) in 34/63 (54%). THAb+ve were 21/412 women (5.1%), the frequency being greater in those who then developed PPT (12/63 [19.0%] vs Gestational positivity of THAb enhance enormously the predictivity for PPT of gestational positivity of TPOAb/TgAb. However, their low frequency (5.1%) and their sensitivity (17.5% [21/63]) go against their application in lieu of TPOAb/TgAb.
Sections du résumé
BACKGROUND
BACKGROUND
Measurement of serum thyroperoxidase autoantibodies (TPOAb) during gestation as a classical marker for the risk of postpartum thyroiditis (PPT) predicts PPT in 1/3 to 1/2 of women. Very few studies have measured serum thyroid hormone Ab (THAb) during gestation, and none as a possible marker for PPT.
METHODS
METHODS
In 412 women who were followed up from 7 to 11 weeks of gestation through 12 months after delivery, we measured THAb (T3.IgM, T3.IgG, T4.IgM, T4.IgG), thyroglobulin autoantibodies (TgAb) and TPOAb at study entry (7-11 week of gestation).
RESULTS
RESULTS
Sixty-three women (15.3%) developed PPT, which progressed to permanent hypothyroidism (PH) in 34/63 (54%). THAb+ve were 21/412 women (5.1%), the frequency being greater in those who then developed PPT (12/63 [19.0%] vs
CONCLUSIONS
CONCLUSIONS
Gestational positivity of THAb enhance enormously the predictivity for PPT of gestational positivity of TPOAb/TgAb. However, their low frequency (5.1%) and their sensitivity (17.5% [21/63]) go against their application in lieu of TPOAb/TgAb.
Identifiants
pubmed: 31428563
doi: 10.1016/j.jcte.2019.100201
pii: S2214-6237(19)30069-9
pii: 100201
pmc: PMC6693681
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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