The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer.
Wnt signaling
YAP signaling
antibody therapy
heparan sulfate proteoglycan
liver cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
04
2019
accepted:
16
07
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
21
8
2019
Statut:
epublish
Résumé
Glypican-3 (GPC3) is a cell-surface glycoprotein consisting of heparan sulfate glycosaminoglycan chains and an inner protein core. It has important functions in cellular signaling including cell growth, embryogenesis, and differentiation. GPC3 has been linked to hepatocellular carcinoma and a few other cancers, however, the mechanistic role of GPC3 in cancer development remains elusive. Recent breakthroughs including the structural modeling of GPC3 and GPC3-Wnt complexes represent important steps toward deciphering the molecular mechanism of action for GPC3 and how it may regulate cancer signaling and tumor growth. A full understanding of the molecular basis of GPC3-mediated signaling requires elucidation of the dynamics of partner receptors, transducer complexes, and downstream players. Herein, we summarize current insights into the role of GPC3 in regulating cancer development through Wnt and other signaling pathways, including YAP and hedgehog cascades. We also highlight the growing body of work which underlies deciphering how GPC3 is a key player in liver oncogenesis.
Identifiants
pubmed: 31428581
doi: 10.3389/fonc.2019.00708
pmc: PMC6688162
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
708Subventions
Organisme : NCATS NIH HHS
ID : TL1 TR002380
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 BC010891
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010891
Pays : United States
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