Red light-triggered nucleic acid-templated reaction based on cyclic oligonucleotide substrates.

Fluorescent Dyes / chemical synthesis Light Molecular Structure Nucleic Acids / analysis Oligonucleotides / chemistry Spectrometry, Fluorescence

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
16 Sep 2019
Historique:
pubmed: 21 8 2019
medline: 11 10 2019
entrez: 21 8 2019
Statut: ppublish

Résumé

A red light-triggered reaction based on cyclic oligonucleotide substrates that is accelerated over 30-fold by specific nucleic acid templates and generates a bright fluorescent probe was developed. We confirmed that this reaction is compatible with fluorescence correlation spectroscopy (FCS) thereby allowing detection of nucleic acids down to 1 nM.

Identifiants

DOI: 10.1039/c9cc03587g PMID: 31429427
pubmed: 31429427
doi: 10.1039/c9cc03587g
doi:

Substances chimiques

Fluorescent Dyes 0
Nucleic Acids 0
Oligonucleotides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

10713-10716

Auteurs

Oleksii Zozulia (O)

Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany. Andriy.Mokhir@fau.de.
ORCID: 0000-0003-3803-4225

Tobias Bachmann (T)

Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany. Andriy.Mokhir@fau.de.

Nina S Deussner-Helfmann (NS)

Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-University, 60438 Frankfurt, Germany.

Frank Beierlein (F)

Computer-Chemistry-Center and Interdisciplinary Center for Molecular Materials, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.

Mike Heilemann (M)

Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-University, 60438 Frankfurt, Germany.

Andriy Mokhir (A)

Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany. Andriy.Mokhir@fau.de.
ORCID: 0000-0002-9079-5569

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Red light-triggered nucleic acid-templated...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Red light-triggered nucleic acid-templated...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Red light-triggered nucleic acid-templated...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › Red light-triggered nucleic acid-templated...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Red light-triggered nucleic acid-templated...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrométrie de fluorescence › Red light-triggered nucleic acid-templated...