Neuroprotection and immunomodulation of progesterone in the gut of a mouse model of Parkinson's disease.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain
/ drug effects
Brain-Derived Neurotrophic Factor
/ metabolism
Disease Models, Animal
Dopaminergic Neurons
/ drug effects
Glial Fibrillary Acidic Protein
/ metabolism
Immunomodulation
/ drug effects
Male
Mice
Mice, Inbred C57BL
Myenteric Plexus
/ drug effects
Neuroprotective Agents
/ pharmacology
Parkinsonian Disorders
/ chemically induced
Progesterone
/ pharmacology
MPTP
Parkinson's disease
gut
neuroprotection
progesterone
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
29
03
2019
revised:
16
08
2019
accepted:
16
08
2019
pubmed:
21
8
2019
medline:
27
5
2021
entrez:
21
8
2019
Statut:
ppublish
Résumé
Gastrointestinal symptoms appear in Parkinson's disease patients many years before motor symptoms, suggesting the implication of dopaminergic neurones of the gut myenteric plexus. Inflammation is also known to be increased in PD. We previously reported neuroprotection with progesterone in the brain of mice lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and hypothesised that it also has neuroprotective and immunomodulatory activities in the gut. To test this hypothesis, we investigated progesterone administered to adult male C57BL/6 mice for 10 days and treated with MPTP on day 5. In an additional experiment, progesterone was administered for 5 days following MPTP treatment. Ilea were collected on day 10 of treatment and microdissected to isolate the myenteric plexus. Dopaminergic neurones were reduced by approximately 60% and pro-inflammatory macrophages were increased by approximately 50% in MPTP mice compared to intact controls. These changes were completely prevented by progesterone administered before and after MPTP treatment and were normalised by 8 mg kg
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Glial Fibrillary Acidic Protein
0
Neuroprotective Agents
0
Progesterone
4G7DS2Q64Y
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9P21XSP91P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12782Subventions
Organisme : Canadian Foundation for Innovation
ID : CFI-25631
Pays : International
Organisme : Canadian Institute of Health Research
ID : MOP-275325
Pays : International
Informations de copyright
© 2019 British Society for Neuroendocrinology.
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