Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications.
adipose-derived stem cells
fibrosis
myofibroblastic differentiation
myofibroblasts
scleroderma
systemic sclerosis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
19 Aug 2019
19 Aug 2019
Historique:
received:
19
07
2019
revised:
06
08
2019
accepted:
16
08
2019
entrez:
22
8
2019
pubmed:
23
8
2019
medline:
23
8
2019
Statut:
epublish
Résumé
Systemic sclerosis (SSc; scleroderma) is characterized by life-threatening progressive multiorgan fibrosis orchestrated by profibrotic myofibroblasts originating from different sources. Because recent data demonstrated that the majority of myofibroblasts in a murine scleroderma model arise from adipocytic progenitors through the adipocyte-myofibroblast transition process, we sought to determine whether the SSc microenvironment may affect the differentiation potential of adipose-derived stem cells (ADSC). Normal human ADSC from three donors were treated with serum from SSc patients (
Identifiants
pubmed: 31430950
pii: jcm8081256
doi: 10.3390/jcm8081256
pmc: PMC6723717
pii:
doi:
Types de publication
Journal Article
Langues
eng
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