A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN).
Head-and-neck cancer
Mepitel® Film
Radiation dermatitis
Randomized trial
Standard care
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
16
05
2019
revised:
16
07
2019
accepted:
16
07
2019
pubmed:
23
8
2019
medline:
6
5
2020
entrez:
22
8
2019
Statut:
ppublish
Résumé
Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).
Identifiants
pubmed: 31431372
pii: S0167-8140(19)33016-6
doi: 10.1016/j.radonc.2019.07.023
pii:
doi:
Substances chimiques
Silicones
0
mepitel
0
Banques de données
ClinicalTrials.gov
['NCT03047174']
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-82Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.