Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
28
01
2019
accepted:
02
06
2019
entrez:
22
8
2019
pubmed:
23
8
2019
medline:
21
3
2020
Statut:
ppublish
Résumé
There is wide variance among individuals in the fraction of insulin cleared by the liver (20% to 80%). Hepatic insulin clearance is 67% lower in African Americans than European Americans. Clearance is also lower in African American children 7-13 years of age. Lower hepatic insulin clearance will result in peripheral hyperinsulinemia: this exacerbates insulin resistance, which stresses the β-cells, possibly resulting in their ultimate failure and onset of type 2 diabetes. We hypothesize that lower insulin clearance can be a primary cause of type 2 diabetes in at-risk individuals.
Identifiants
pubmed: 31431441
pii: 68/9/1709
doi: 10.2337/db19-0098
pmc: PMC6702636
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1709-1716Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK027619
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK027619
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 by the American Diabetes Association.
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