The role of allogeneic HSCT after CAR T cells for acute lymphoblastic leukemia.
Journal
Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
entrez:
22
8
2019
pubmed:
23
8
2019
medline:
9
9
2020
Statut:
ppublish
Résumé
Enthusiasm with results of early phase trials using chimeric-antigen-receptor (CAR)-T cells targeting CD19 have led to fast approval of this novel immunotherapy for the treatment of acute lymphoblastic leukemia and diffuse large B-cell lymphoma, and to an explosion of clinical trials with such cells. Despite potential for long-term immune surveillance by CAR-T cells, many patients treated on these trials are referred to a consolidative hematopoietic stem cell transplantation, as are all patients responding to CAR-T cells in a study we conducted. Overall, paucity of long-term data and lack of randomized trials focusing on consolidative HSCT impact clinical evidence. Nevertheless, limited T cell persistence and inherent leukemia resistance mechanisms have led us, as well as others, to this clinical decision making, and are hereby reviewed.
Identifiants
pubmed: 31431700
doi: 10.1038/s41409-019-0604-3
pii: 10.1038/s41409-019-0604-3
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
810-814Références
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