Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation.
eye-of-the-tiger-sign
hallervorden-spatz
mri
nbia
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
18 Jun 2019
18 Jun 2019
Historique:
entrez:
22
8
2019
pubmed:
23
8
2019
medline:
23
8
2019
Statut:
epublish
Résumé
A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation (NBIA). Genetic panel for NBIA was ordered, specifically pantothenate kinase-associated neurodegeneration (PKAN), including pantothenate kinase 2 (PanK2) - the genetic marker for the pantothenate kinase enzyme.
Identifiants
pubmed: 31431841
doi: 10.7759/cureus.4936
pmc: PMC6695239
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e4936Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Ann Neurol. 2006 Feb;59(2):248-56
pubmed: 16437574
Neurology. 2008 Apr 29;70(18):1614-9
pubmed: 18443312