Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance.

Adenocarcinoma of Lung / drug therapy Aged Aged, 80 and over Animals Carcinoma, Large Cell / drug therapy Carcinoma, Non-Small-Cell Lung / drug therapy Carcinoma, Squamous Cell / drug therapy Cell Line, Tumor Cell Proliferation / drug effects Drug Resistance, Neoplasm / drug effects Drug Screening Assays, Antitumor ErbB Receptors / antagonists & inhibitors Female Humans Lung Neoplasms / drug therapy Male Mice Mice, Hairless Mice, SCID Middle Aged Mutation Protein Kinase Inhibitors / pharmacology Tumor Microenvironment / drug effects Xenograft Model Antitumor Assays
EGFR mutation EGFR-TKI SHO mouse non-small cell lung cancer patient-derived xenograft

Journal

Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 19 05 2019
revised: 06 08 2019
accepted: 13 08 2019
pubmed: 23 8 2019
medline: 12 10 2019
entrez: 22 8 2019
Statut: ppublish

Résumé

Patient-derived xenograft (PDX) models are a useful tool in cancer biology research. However, the number of lung cancer PDX is limited. In the present study, we successfully established 10 PDX, including three adenocarcinoma (AD), six squamous cell carcinoma (SQ) and one large cell carcinoma (LA), from 30 patients with non-small cell lung cancer (NSCLC) (18 AD, 10 SQ, and 2 LA), mainly in SCID hairless outbred (SHO) mice (Crlj:SHO-Prkdc

Identifiants

DOI: 10.1111/cas.14171 PMID: 31432603 PMC: PMC6778641
pubmed: 31432603
doi: 10.1111/cas.14171
pmc: PMC6778641
doi:

Substances chimiques

Protein Kinase Inhibitors 0
EGFR protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Banques de données

GENBANK
['GSE130160']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3215-3224

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 16H05308
Organisme : Japan Society for the Promotion of Science
ID : 18K08141
Organisme : Japan Agency for Medical Research and Development
ID : 16cm0106513h0001
Organisme : Kanazawa University Extramural Collaborative Research Grant of Cancer Research Institute

Informations de copyright

© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

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Auteurs

Kenji Kita (K)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Central Research Resource Branch, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
ORCID: 0000-0002-4622-6633

Koji Fukuda (K)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.

Hiro Takahashi (H)

Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
ORCID: 0000-0002-8230-9524

Azusa Tanimoto (A)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Akihiro Nishiyama (A)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Sachiko Arai (S)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Central Research Resource Branch, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Shinji Takeuchi (S)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.

Kaname Yamashita (K)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Koshiro Ohtsubo (K)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Sakiko Otani (S)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Naohiro Yanagimura (N)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Chiaki Suzuki (C)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Hiroko Ikeda (H)

Division of Pathology, Kanazawa University Hospital, Kanazawa, Japan.

Masaya Tamura (M)

Department of Thoracic, Cardiovascular and General Surgery, Kanazawa University, Kanazawa, Japan.

Isao Matsumoto (I)

Department of Thoracic, Cardiovascular and General Surgery, Kanazawa University, Kanazawa, Japan.

Seiji Yano (S)

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.
ORCID: 0000-0002-6151-2988

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Eucaryotes › Animaux › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Carcinome à grandes cellules › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris hairless › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Patient-derived xenograft models of non-small...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Patient-derived xenograft models of non-small...