Immunomodulatory roles of human herpesvirus-encoded microRNA in host-virus interaction.
human herpesvirus
immune responses
viral microRNA
Journal
Reviews in medical virology
ISSN: 1099-1654
Titre abrégé: Rev Med Virol
Pays: England
ID NLM: 9112448
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
06
2019
revised:
31
07
2019
accepted:
01
08
2019
pubmed:
23
8
2019
medline:
28
8
2021
entrez:
22
8
2019
Statut:
ppublish
Résumé
Human herpesviruses (HHV) are large, double stranded, DNA viruses with high seroprevalence across the globe. Clinical manifestation of primary HHV infection resolve shortly, however, this period is prolonged in immunocompromised patients or individuals with suppressed immunity. Examining molecular mechanisms of HHV-encoded virulence factors can provide finer details of HHV-host interaction. A unique genetic feature of most members of HHV is that they encode multiple microRNAs (miR). In this review, I will provide mechanistic insights into the immunomodulatory functions of herpesvirus-encoded viral miR (v-miR) that favor viral persistence and spread by ingenious immune evasion schemes. Similar to host miR, v-miR can simultaneously regulate expression of multiple transcripts including host- and virus-derived. V-miRs, by virtue of their direct interaction with various transcripts, can regulate expression of critical components of host innate and adaptive immune system. V-miRs are also exported through exosomal route and gain entry into various cells even at distant sites, thereby allowing HHV to manipulate cellular and tissue immunity. Targeting v-miR may serve as a novel and promising therapeutic candidate to mitigate HHV-mediated clinical manifestations.
Identifiants
pubmed: 31432608
doi: 10.1002/rmv.2081
pmc: PMC7398577
mid: NIHMS1607082
doi:
Substances chimiques
MicroRNAs
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2081Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027980
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE027147
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE026259
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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