miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.

Animals Antigens / metabolism Cell Cycle / genetics Cell Differentiation / genetics Cell Survival / genetics Gene Expression Regulation Gene Regulatory Networks Genetic Loci Immunologic Memory Lymphocytic choriomeningitis virus / physiology Mice, Transgenic MicroRNAs / genetics T-Lymphocytes / cytology
Argonaute HITS-CLIP CD127 IL-7 receptor T cell memory cell cycle miR-15a miR-15b miR-16 miRNA microRNA

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
20 08 2019
Historique:
received: 24 10 2018
revised: 03 05 2019
accepted: 18 07 2019
entrez: 22 8 2019
pubmed: 23 8 2019
medline: 1 9 2020
Statut: ppublish

Résumé

Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccination strategies. microRNAs (miRNAs) are key nodes in regulatory networks that shape effective T cell responses through the fine-tuning of thousands of genes. Here, using compound conditional mutant mice to eliminate miR-15/16 family miRNAs in T cells, we show that miR-15/16 restrict T cell cycle, survival, and memory T cell differentiation. High throughput sequencing of RNA isolated by cross-linking immunoprecipitation of AGO2 combined with gene expression analysis in miR-15/16-deficient T cells indicates that these effects are mediated through the direct inhibition of an extensive network of target genes within pathways critical to cell cycle, survival, and memory.

Identifiants

DOI: 10.1016/j.celrep.2019.07.064 PMID: 31433990 PMC: PMC6715152
pubmed: 31433990
pii: S2211-1247(19)30968-4
doi: 10.1016/j.celrep.2019.07.064
pmc: PMC6715152
mid: NIHMS1538157
pii:
doi:

Substances chimiques

Antigens 0
MicroRNAs 0
Mirn15 microRNA, mouse 0
Mirn16 microRNA, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2169-2181.e4

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK063720
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL107202
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109102
Pays : United States
Organisme : NIH HHS
ID : S10 OD021822
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI113002
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008568
Pays : United States

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

John D Gagnon (JD)

Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Robin Kageyama (R)

Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Hesham M Shehata (HM)

Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158, USA.

Marlys S Fassett (MS)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.

Darryl J Mar (DJ)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Eric J Wigton (EJ)

Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Kristina Johansson (K)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Adam J Litterman (AJ)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Pamela Odorizzi (P)

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Dimitre Simeonov (D)

Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Brian J Laidlaw (BJ)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

Marisella Panduro (M)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Sana Patel (S)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Lukas T Jeker (LT)

Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

Margaret E Feeney (ME)

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Michael T McManus (MT)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Alexander Marson (A)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Mehrdad Matloubian (M)

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Shomyseh Sanjabi (S)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158, USA.

K Mark Ansel (KM)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: mark.ansel@ucsf.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Facteurs biologiques › Antigènes › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Arenaviridae › Arenavirus › Arénavirus de l'Ancien Monde › Virus de la chorioméningite lymphocytaire › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › miR-15/16 Restrain Memory T Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › miR-15/16 Restrain Memory T Cell...