Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations.
Aged
Case-Control Studies
Colorectal Neoplasms
/ epidemiology
Europe
/ epidemiology
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Nutritional Physiological Phenomena
Polymorphism, Single Nucleotide
/ genetics
Prospective Studies
Risk Factors
Signal Transduction
Transforming Growth Factor beta
/ metabolism
Vitamin D
/ analogs & derivatives
colorectal neoplasms
incidence
single nucleotide polymorphism (SNP)
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
20 08 2019
20 08 2019
Historique:
received:
21
06
2019
revised:
09
08
2019
accepted:
12
08
2019
entrez:
23
8
2019
pubmed:
23
8
2019
medline:
1
2
2020
Statut:
epublish
Résumé
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We also evaluated the association between these SNPs and circulating 25(OH)D in a subset of controls. We confirmed previously reported CRC risk associations between SNPs in the
Identifiants
pubmed: 31434255
pii: nu11081954
doi: 10.3390/nu11081954
pmc: PMC6722852
pii:
doi:
Substances chimiques
Transforming Growth Factor beta
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : World Cancer Research Fund International
ID : 2011-443
Pays : International
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
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