A Stage-Based Approach to Therapy in Parkinson's Disease.
Parkinson’s disease
acetylcholinesterase inhibitors
amantadine
anticholinergics
dopamine-agonists
l-dopa
monoamine oxidase inhibitors
motor symptoms
non-motor symptoms
non-pharmacological therapy
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
20 08 2019
20 08 2019
Historique:
received:
11
06
2019
revised:
31
07
2019
accepted:
14
08
2019
entrez:
23
8
2019
pubmed:
23
8
2019
medline:
23
6
2020
Statut:
epublish
Résumé
Parkinson's disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor. Nevertheless, some non-motor symptoms, including depression, REM sleep behavior disorder, and olfactive impairment, are even earlier features of PD. At later stages, apathy, impulse control disorder, neuropsychiatric disturbances, and cognitive impairment can present, and they often become a heavy burden for both patients and caregivers. Indeed, PD increasingly compromises activities of daily life, even though a high variability in clinical presentation can be observed among people affected. Nowadays, symptomatic drugs and non-pharmaceutical treatments represent the best therapeutic options to improve quality of life in PD patients. The aim of the present review is to provide a practical, stage-based guide to pharmacological management of both motor and non-motor symptoms of PD. Furthermore, warning about drug side effects, contraindications, as well as dosage and methods of administration, are highlighted here, to help the physician in yielding the best therapeutic strategies for each symptom and condition in patients with PD.
Identifiants
pubmed: 31434341
pii: biom9080388
doi: 10.3390/biom9080388
pmc: PMC6723065
pii:
doi:
Substances chimiques
Antiparkinson Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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