The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.

Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics Animals Apoptosis Bone and Bones / metabolism DNA Damage Dietary Fats / adverse effects HSP70 Heat-Shock Proteins / genetics Hydrogen Peroxide / adverse effects Mice Mice, Knockout NF-kappa B / genetics Osteoblasts / metabolism Signal Transduction Stress, Physiological Ultraviolet Rays / adverse effects
DNA damage bone epigenetics osteoblasts osteoporosis

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
03 09 2019
Historique:
pubmed: 23 8 2019
medline: 25 3 2020
entrez: 23 8 2019
Statut: ppublish

Résumé

The fat mass and obesity-associated gene (

Identifiants

DOI: 10.1073/pnas.1905489116 PMID: 31434789 PMC: PMC6731662
pubmed: 31434789
pii: 1905489116
doi: 10.1073/pnas.1905489116
pmc: PMC6731662
doi:

Substances chimiques

Dietary Fats 0
HSP70 Heat-Shock Proteins 0
Hsp70.3 protein, mouse 0
NF-kappa B 0
Hydrogen Peroxide BBX060AN9V
FTO protein, mouse EC 1.14.11.-
Alpha-Ketoglutarate-Dependent Dioxygenase FTO EC 1.14.11.33

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

17980-17989

Subventions

Organisme : BLRD VA
ID : I01 BX001234
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004984
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099134
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

Mamm Genome. 1999 Oct;10(10):983-6
pubmed: 10501967
Science. 2000 Sep 1;289(5484):1550-4
pubmed: 10968790
Mol Cell Biol. 2000 Oct;20(19):7146-59
pubmed: 10982831
J Biol Chem. 2002 Nov 15;277(46):44005-12
pubmed: 12215457
J Biol Chem. 2003 Sep 12;278(37):35272-8
pubmed: 12829720
Genes Dev. 2004 Jun 15;18(12):1466-81
pubmed: 15198984
Aging Cell. 2004 Dec;3(6):379-89
pubmed: 15569355
J Biol Chem. 2005 Apr 29;280(17):17497-506
pubmed: 15731115
Cell Stress Chaperones. 2006 Summer;11(2):162-9
pubmed: 16817322
Trends Mol Med. 2006 Sep;12(9):440-50
pubmed: 16899408
Carcinogenesis. 2007 Mar;28(3):537-44
pubmed: 16950797
J Clin Invest. 2007 Apr;117(4):889-901
pubmed: 17380205
Science. 2007 May 11;316(5826):889-94
pubmed: 17434869
Nat Genet. 2007 Jun;39(6):724-6
pubmed: 17496892
FEBS Lett. 2007 Jul 31;581(19):3702-10
pubmed: 17544402
J Biol Chem. 2007 Aug 31;282(35):25649-58
pubmed: 17553792
J Biol Chem. 2007 Sep 14;282(37):27285-97
pubmed: 17623659
PLoS Genet. 2007 Jul;3(7):e115
pubmed: 17658951
Science. 2007 Nov 30;318(5855):1469-72
pubmed: 17991826
BMC Biochem. 2007 Nov 08;8:23
pubmed: 17996046
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18754-9
pubmed: 18000063
Anesthesiology. 2008 Aug;109(2):339-48
pubmed: 18648242
Cell Stress Chaperones. 2009 Jan;14(1):1-21
pubmed: 18686016
Nature. 2009 Apr 16;458(7240):894-8
pubmed: 19234441
Am J Hum Genet. 2009 Jul;85(1):106-11
pubmed: 19559399
PLoS Genet. 2009 Aug;5(8):e1000599
pubmed: 19680540
Nat Rev Rheumatol. 2010 Feb;6(2):99-105
pubmed: 20125177
Nat Rev Mol Cell Biol. 2010 Jul;11(7):479-89
pubmed: 20551964
Nat Genet. 2010 Dec;42(12):1086-92
pubmed: 21076408
PLoS One. 2010 Nov 16;5(11):e14005
pubmed: 21103374
Nat Chem Biol. 2011 Oct 16;7(12):885-7
pubmed: 22002720
PLoS One. 2011;6(11):e27312
pubmed: 22125610
Nature. 2012 Apr 29;485(7397):201-6
pubmed: 22575960
Cell. 2012 Jun 22;149(7):1635-46
pubmed: 22608085
Ther Adv Musculoskelet Dis. 2012 Apr;4(2):61-76
pubmed: 22870496
J Bone Miner Res. 2013 Jan;28(1):2-17
pubmed: 23197339
Methods Enzymol. 2014;537:123-39
pubmed: 24480344
Nat Rev Genet. 2014 May;15(5):293-306
pubmed: 24662220
Nat Med. 2014 Sep;20(9):1009-17
pubmed: 25108526
Oncogene. 2015 Aug 6;34(32):4153-61
pubmed: 25347739
Oncogene. 2016 Jan 21;35(3):301-13
pubmed: 25823024
Nat Commun. 2015 Apr 17;6:6792
pubmed: 25881961
PLoS One. 2015 Jul 28;10(7):e0133788
pubmed: 26218273
N Engl J Med. 2015 Sep 3;373(10):895-907
pubmed: 26287746
Int J Oncol. 2016 Jan;48(1):191-8
pubmed: 26573875
Sci Signal. 2015 Dec 15;8(407):ra127
pubmed: 26671148
Sci Adv. 2016 Jan 08;2(1):e1501292
pubmed: 26824076
J Bone Miner Res. 2016 Jul;31(7):1381-90
pubmed: 26890063
Nucleic Acids Res. 2016 Jun 2;44(10):e91
pubmed: 26896799
J Lipid Res. 2016 Aug;57(8):1329-38
pubmed: 27146479
Cell Syst. 2017 Jan 25;4(1):46-59.e4
pubmed: 27866947
Nature. 2017 Mar 23;543(7646):573-576
pubmed: 28297716
Nat Genet. 2017 Oct;49(10):1468-1475
pubmed: 28869591
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Nucleic Acids Res. 2018 Feb 16;46(3):1412-1423
pubmed: 29186567
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):843-850
pubmed: 29203346
Clin Orthop Relat Res. 1971 Oct;80:147-54
pubmed: 5133320
J Bone Miner Res. 1998 May;13(5):793-802
pubmed: 9610743

Auteurs

Qian Zhang (Q)

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287.
ORCID: 0000-0003-3032-9088

Ryan C Riddle (RC)

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287.
Baltimore Veterans Administration Medical Center, Baltimore, MD 21201.

Qian Yang (Q)

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287.

Clifford R Rosen (CR)

Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074.

Denis C Guttridge (DC)

Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425.

Naomi Dirckx (N)

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287.

Marie-Claude Faugere (MC)

Department of Medicine, University of Kentucky, Lexington, KY 40506.

Charles R Farber (CR)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908.

Thomas L Clemens (TL)

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287; tclemen5@jhmi.edu.
Baltimore Veterans Administration Medical Center, Baltimore, MD 21201.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › Alpha-ketoglutarate-dependent dioxygenase FTO › The RNA demethylase FTO is required for...
questionsmedicales.fr › Eucaryotes › Animaux › The RNA demethylase FTO is required for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › The RNA demethylase FTO is required for...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › The RNA demethylase FTO is required for...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › The RNA demethylase FTO is required for...
questionsmedicales.fr › Aliments et boissons › Aliments › Matières grasses alimentaires › The RNA demethylase FTO is required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Protéines du choc thermique HSP70 › The RNA demethylase FTO is required for...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › The RNA demethylase FTO is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The RNA demethylase FTO is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The RNA demethylase FTO is required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › The RNA demethylase FTO is required for...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › The RNA demethylase FTO is required for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The RNA demethylase FTO is required for...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › The RNA demethylase FTO is required for...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › The RNA demethylase FTO is required for...