Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
21 08 2019
21 08 2019
Historique:
received:
28
03
2019
accepted:
07
07
2019
revised:
27
05
2019
entrez:
23
8
2019
pubmed:
23
8
2019
medline:
29
2
2020
Statut:
epublish
Résumé
Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP) index, a dynamic secretory molecular pattern indicative of cellular senescence. We also tested the potential moderators of the association between major depression and the SASP index. We included 1165 young and middle-aged adults (527 with a current major depressive episode (cMDE) and 638 with no lifetime history of depression) from a community-based cohort from the Netherlands. We calculated the SASP index based on a previously developed composite index involving 19 biomarkers. cMDE had higher SASP index values (t
Identifiants
pubmed: 31434875
doi: 10.1038/s41398-019-0541-3
pii: 10.1038/s41398-019-0541-3
pmc: PMC6704136
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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