Implementation of an experimental isolated lung perfusion model on surgically resected human lobes.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 08 2019
21 08 2019
Historique:
received:
13
03
2019
accepted:
12
08
2019
entrez:
23
8
2019
pubmed:
23
8
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Isolated lung perfusion (ILP) is an ideal model to study treatment effects on a variety of pathologies. As published research mostly relies on rejected donor lungs or animal organs, this study investigates the use of surgically resected human lobes as an alternative and novel model for personalized experimental research. Ten surgically resected lobes were perfused in acellular and normothermic condition. The indication for surgery was lung cancer. Perfusion and ventilation were adapted to the size of the lobes and both functional and metabolic parameters were assessed during ILP. Patients (age 67.5 y (59-81)|♀n = 3|♂n = 7) underwent anatomic pulmonary lobectomy. Ischemic time between arterial ligation and ILP was 226 minutes (161-525). Median duration of ILP was 135 (87-366) minutes. Gas exchange and mechanical respiratory parameters remained steady during ILP (pulmonary venous pO
Identifiants
pubmed: 31434960
doi: 10.1038/s41598-019-48719-8
pii: 10.1038/s41598-019-48719-8
pmc: PMC6704181
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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