A Case of Life-threatening Amlodipine and Atenolol Overdose.
Amlodipine
Atenolol
Bradycardia
Hyperinsulinaemia/euglycaemia therapy
Hypotension
Journal
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
ISSN: 0972-5229
Titre abrégé: Indian J Crit Care Med
Pays: India
ID NLM: 101208863
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
entrez:
23
8
2019
pubmed:
23
8
2019
medline:
23
8
2019
Statut:
ppublish
Résumé
Treating a patient of amlodipine-atenolol poisoning is nightmare for a physician. In high dose both the drugs individually cause severe bradycardia and hypotension. In combination they cause severe cardiovascular depression. Here we report a case of 66-year-old obese, hypertensive, depressed male, who presented to emergency 9 hours after consumption of 25 tablets of amlodipine-atenolol (5 mg+50 mg). On evaluation, he had refractory bradycardia, hypotension and acute kidney injury (AKI). Eventually he developed cardiac arrest. He was revived after 5 minutes of cardio-pulmonary resuscitation (CPR). He was successfully managed with gastric lavage, fluids, inotropes, atropine, isoprenaline and subsequently with calcium gluconate infusion, high-dose insulin euglycemia therapy (HIET) and lipid emulsion therapy. Glucagon infusion was also planned but it was not available. Patient hemodynamics improved and on 8th day he got the discharge. Our case exemplifies the importance of timely and aggressive management of lethal overdose of amlodipine-atenolol poisoning.
Identifiants
pubmed: 31435148
doi: 10.5005/jp-journals-10071-23181
pmc: PMC6698349
doi:
Types de publication
Case Reports
Langues
eng
Pagination
281-283Déclaration de conflit d'intérêts
Source of support: Nil Conflict of interest: None
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