Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative.

Aged Aged, 80 and over Biomarkers / blood Carotenoids / blood Cross-Sectional Studies Frailty / blood Humans Linear Models Logistic Models Micronutrients / blood Oxidation-Reduction Tyrosine / analogs & derivatives Vitamin A / blood Vitamin E / blood
3-Nitrotyrosine Carotenoids Fat-soluble micronutrients Frail Protein carbonyls

Journal

Journal of cachexia, sarcopenia and muscle
ISSN: 2190-6009
Titre abrégé: J Cachexia Sarcopenia Muscle
Pays: Germany
ID NLM: 101552883

Informations de publication

Date de publication:
12 2019
Historique:
received: 22 01 2019
accepted: 24 06 2019
pubmed: 23 8 2019
medline: 28 7 2020
entrez: 23 8 2019
Statut: ppublish

Résumé

A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years. Plasma levels of vitamins A (retinol), D Robust participants had significantly higher vitamin D Our study indicates that both low FMN and high PrCarb concentrations are associated with pre-frailty and frailty.

Sections du résumé

BACKGROUND
A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.
METHODS
Plasma levels of vitamins A (retinol), D
RESULTS
Robust participants had significantly higher vitamin D
CONCLUSIONS
Our study indicates that both low FMN and high PrCarb concentrations are associated with pre-frailty and frailty.

Identifiants

DOI: 10.1002/jcsm.12479 PMID: 31436047 PMC: PMC6903435
pubmed: 31436047
doi: 10.1002/jcsm.12479
pmc: PMC6903435
doi:

Substances chimiques

Biomarkers 0
Micronutrients 0
Vitamin A 11103-57-4
Vitamin E 1406-18-4
Carotenoids 36-88-4
3-nitrotyrosine 3604-79-3
Tyrosine 42HK56048U

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1339-1346

Informations de copyright

© 2019 The Authors Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

Références

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Auteurs

Bastian Kochlik (B)

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany.

Wolfgang Stuetz (W)

Department of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany.

Karine Pérès (K)

Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, Bordeaux, France.

Sophie Pilleron (S)

Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, Bordeaux, France.

Catherine Féart (C)

Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, Bordeaux, France.

Francisco José García García (FJ)

Division of Geriatric Medicine, Hospital Virgen del Valle Complejo Hospitalario de Toledo, Toledo, Spain.

Stefania Bandinelli (S)

Geriatric Unit, Local Health Tuscany Center Agency, Florence, Italy.

David Gomez-Cabrero (D)

Unit of Computational Medicine, Karolinska Institute, Stockholm, Sweden.

Leocadio Rodriguez-Mañas (L)

Division of Geriatrics, Hospital Universitario de Getafe, Getafe, Spain.

Tilman Grune (T)

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany.
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
German Center for Cardiovascular Research (DZHK), Berlin, Germany.

Daniela Weber (D)

Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany.
ORCID: 0000-0002-2054-6233

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