Re-elevation of serum amlodipine level after lipid emulsion therapy in an overdose case.
amlodipine
calcium channel antagonist
emergency
intravenous lipid emulsion therapy
liquid chromatography-mass spectrometry
Journal
Journal of clinical pharmacy and therapeutics
ISSN: 1365-2710
Titre abrégé: J Clin Pharm Ther
Pays: England
ID NLM: 8704308
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
25
04
2019
revised:
07
06
2019
accepted:
16
07
2019
pubmed:
23
8
2019
medline:
19
3
2020
entrez:
23
8
2019
Statut:
ppublish
Résumé
Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable. A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including amlodipine. After approximately 20 hours of ILE therapy, the serum amlodipine level that had decreased from 90.2 to 49.9 ng/mL increased to 70.8 ng/mL. A single bolus (1.5 mL/kg) of ILE therapy is probably insufficient to completely capture and partition serum amlodipine following amlodipine overdose.
Substances chimiques
Calcium Channel Blockers
0
Fat Emulsions, Intravenous
0
Lipids
0
Amlodipine
1J444QC288
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
970-973Informations de copyright
© 2019 John Wiley & Sons Ltd.
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