Dietary zinc and the control of Streptococcus pneumoniae infection.
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
05
10
2018
accepted:
03
07
2019
entrez:
23
8
2019
pubmed:
23
8
2019
medline:
16
1
2020
Statut:
epublish
Résumé
Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences.
Identifiants
pubmed: 31437249
doi: 10.1371/journal.ppat.1007957
pii: PPATHOGENS-D-18-01948
pmc: PMC6705770
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1007957Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Front Cell Infect Microbiol. 2015 Dec 08;5:91
pubmed: 26697415
Thorax. 2014 Nov;69(11):1034-42
pubmed: 25179663
Infect Immun. 2014 Oct;82(10):4315-24
pubmed: 25069983
PLoS One. 2014 Feb 18;9(2):e89427
pubmed: 24558498
J Biol Chem. 2015 Jul 31;290(31):18991-8
pubmed: 26055713
J Infect Dis. 1997 Aug;176(2):439-44
pubmed: 9237710
Mol Microbiol. 2004 Aug;53(3):889-901
pubmed: 15255900
Biochemistry. 2013 Oct 29;52(43):7689-701
pubmed: 24067066
Infect Immun. 1998 Jul;66(7):3164-9
pubmed: 9632581
PLoS Pathog. 2011 Nov;7(11):e1002357
pubmed: 22072971
Lancet Infect Dis. 2004 Mar;4(3):144-54
pubmed: 14998500
Cochrane Database Syst Rev. 2010 Dec 08;(12):CD005978
pubmed: 21154362
Educ Health (Abingdon). 2003 Jul;16(2):230
pubmed: 14741909
J Pediatr. 1999 Dec;135(6):689-97
pubmed: 10586170
Metallomics. 2011 Jun;3(6):609-18
pubmed: 21603707
Mol Microbiol. 2017 May;104(4):636-651
pubmed: 28249108
Lancet. 2008 Jan 19;371(9608):243-60
pubmed: 18207566
Cell Host Microbe. 2011 Sep 15;10(3):248-59
pubmed: 21925112
Nat Chem Biol. 2014 Jan;10(1):35-41
pubmed: 24212134
Ann N Y Acad Sci. 1982;389:39-48
pubmed: 7046585
Nat Commun. 2015 Mar 03;6:6418
pubmed: 25731976
Lancet. 2009 Sep 12;374(9693):893-902
pubmed: 19748398
J Infect Dis. 2014 May 15;209(10):1500-8
pubmed: 24449444
Infect Immun. 2003 Apr;71(4):2009-13
pubmed: 12654820
Pediatr Infect Dis J. 2009 Jan;28(1 Suppl):S10-8
pubmed: 19106757
Mol Microbiol. 2014 Feb;91(4):834-51
pubmed: 24428621
Mol Microbiol. 2007 Aug;65(4):1049-63
pubmed: 17640279
Mol Microbiol. 1997 Aug;25(4):727-39
pubmed: 9379902
Cochrane Database Syst Rev. 2014 May 15;(5):CD009384
pubmed: 24826920
Am J Public Health. 2000 Feb;90(2):223-9
pubmed: 10667183
Microbes Infect. 2012 Jul;14(7-8):573-83
pubmed: 22342898
Clin Microbiol Infect. 2001 Mar;7(3):125-9
pubmed: 11318810
Microbiology. 2006 Feb;152(Pt 2):285-293
pubmed: 16436416
FASEB J. 2016 May;30(5):1901-12
pubmed: 26839376
Metallomics. 2014 Jul;6(7):1175-80
pubmed: 24531756
Mol Microbiol. 2001 May;40(3):572-85
pubmed: 11359564
PLoS One. 2012;7(11):e50568
pubmed: 23209782
Indian J Pediatr. 2011 Sep;78(9):1079-84
pubmed: 21660402
Int Immunol. 2008 Sep;20(9):1139-46
pubmed: 18596024
Annu Rev Nutr. 2009;29:133-52
pubmed: 19400701
Vaccine. 2012 Apr 5;30(17):2728-37
pubmed: 22330126
Infect Immun. 2002 Aug;70(8):4389-98
pubmed: 12117949
Bull World Health Organ. 2008 May;86(5):408-16
pubmed: 18545744
Nutr Rev. 2010 Jan;68(1):30-7
pubmed: 20041998
FASEB J. 2014 Aug;28(8):3600-8
pubmed: 24776746
Nat Immunol. 2011 Jun 19;12(8):709-14
pubmed: 21772279
Nutrients. 2017 Nov 25;9(12):
pubmed: 29186856
J Immunol. 2007 May 1;178(9):5828-38
pubmed: 17442967
Infect Immun. 2015 Nov 16;84(2):407-15
pubmed: 26573735
Clin Infect Dis. 2004 Mar 1;38(5):632-9
pubmed: 14986245
J Mol Biol. 2008 Sep 5;381(3):594-606
pubmed: 18632116
FEMS Microbiol Rev. 2014 Nov;38(6):1235-49
pubmed: 25211180
Br J Nutr. 2001 Aug;86(2):301-6
pubmed: 11502245
Biometals. 2015 Aug;28(4):693-700
pubmed: 25940830
PLoS Pathog. 2012;8(12):e1003068
pubmed: 23236280
Biofactors. 2014 Jan-Feb;40(1):27-40
pubmed: 23804522
Vaccine. 2004 Jun 2;22(17-18):2209-20
pubmed: 15149779
FEMS Microbiol Lett. 2001 Jan 1;194(1):105-10
pubmed: 11150674
Clin Nutr. 2015 Apr;34(2):181-8
pubmed: 25176404
BMJ. 2003 Feb 22;326(7386):409-10
pubmed: 12595353
Biometals. 2015 Jun;28(3):491-508
pubmed: 25652937
Science. 2008 Feb 15;319(5865):962-5
pubmed: 18276893
N Engl J Med. 2006 Apr 6;354(14):1455-63
pubmed: 16598044
Cell Rep. 2013 Feb 21;3(2):386-400
pubmed: 23403290
Am J Clin Nutr. 2007 Mar;85(3):837-44
pubmed: 17344507
Commun Dis Intell Q Rep. 2012 Jun 30;36(2):E151-65
pubmed: 23186214
Science. 2011 Jan 28;331(6016):430-4
pubmed: 21273480
Mol Microbiol. 2011 Nov;82(4):904-16
pubmed: 22023106
Cell Microbiol. 2012 Apr;14(4):460-6
pubmed: 22212419