Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression.

Brain Neoplasms / diagnostic imaging Disease Progression Humans Immune Checkpoint Inhibitors / therapeutic use Immunotherapy / methods Molecular Targeted Therapy / methods Neuroimaging / methods Treatment Outcome
FET PET brain metastasis immune checkpoint inhibitors lung cancer melanoma radiomics

Journal

Neuro-oncology
ISSN: 1523-5866
Titre abrégé: Neuro Oncol
Pays: England
ID NLM: 100887420

Informations de publication

Date de publication:
11 01 2020
Historique:
pubmed: 23 8 2019
medline: 11 2 2021
entrez: 23 8 2019
Statut: ppublish

Résumé

The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT-either alone (especially ICI) or in combination with radiotherapy-imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response.

Identifiants

DOI: 10.1093/neuonc/noz147 PMID: 31437274 PMC: PMC6954406
pubmed: 31437274
pii: 5553498
doi: 10.1093/neuonc/noz147
pmc: PMC6954406
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

17-30

Subventions

Organisme : NCI NIH HHS
ID : P50 CA211015
Pays : United States

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Norbert Galldiks (N)

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Institute of Neuroscience and Medicine, Research Center Juelich, Juelich, Germany.
Center of Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Düsseldorf, Germany.

Martin Kocher (M)

Institute of Neuroscience and Medicine, Research Center Juelich, Juelich, Germany.
Department of Stereotaxy and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Garry Ceccon (G)

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Jan-Michael Werner (JM)

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Anna Brunn (A)

Institute of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Martina Deckert (M)

Institute of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Whitney B Pope (WB)

Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Riccardo Soffietti (R)

Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.

Emilie Le Rhun (E)

Neuro-Oncology, General and Stereotaxic Neurosurgery Service, University Hospital Lille, Lille, France.
Breast Cancer Department, Oscar Lambret Center, Lille, France.
Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

Michael Weller (M)

Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

Jörg C Tonn (JC)

Department of Neurosurgery, Ludwig Maximilians University of Munich, Munich, Germany.
German Cancer Consortium, partner site Munich, Germany.

Gereon R Fink (GR)

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Institute of Neuroscience and Medicine, Research Center Juelich, Juelich, Germany.

Karl-Josef Langen (KJ)

Institute of Neuroscience and Medicine, Research Center Juelich, Juelich, Germany.
Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany.

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Imaging challenges of immunotherapy and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Imaging challenges of immunotherapy and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imaging challenges of immunotherapy and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Imaging challenges of immunotherapy and...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Imaging challenges of immunotherapy and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Imaging challenges of immunotherapy and...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imaging challenges of immunotherapy and...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Imaging challenges of immunotherapy and...