Effects of treadmill running and limb immobilization on knee cartilage degeneration and locomotor joint kinematics in rats following knee meniscal transection.
Animals
Biomechanical Phenomena
Cartilage, Articular
/ diagnostic imaging
Disease Models, Animal
Immobilization
Locomotion
/ physiology
Male
Menisci, Tibial
/ surgery
Osteoarthritis, Knee
/ etiology
Osteophyte
/ diagnostic imaging
Rats
Running
Tibia
/ diagnostic imaging
Tibial Meniscus Injuries
/ complications
Weight-Bearing
/ physiology
X-Ray Microtomography
Computed tomography
Knee injury
Osteoarthritis
Rehabilitation
X-ray motion analysis
Journal
Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
09
02
2019
revised:
25
07
2019
accepted:
07
08
2019
pubmed:
23
8
2019
medline:
23
9
2020
entrez:
23
8
2019
Statut:
ppublish
Résumé
This study examined the effects of reduced and elevated weight bearing on post-traumatic osteoarthritis (PTOA) development, locomotor joint kinematics, and degree of voluntary activity in rats following medial meniscal transection (MMT). Twenty-one adult rats were subjected to MMT surgery of the left hindlimb and then assigned to one of three groups: (1) regular (i.e., no intervention), (2) hindlimb immobilization, or (3) treadmill running. Sham surgery was performed in four additional rats. Voluntary wheel run time/distance was measured, and 3D hindlimb kinematics were quantified during treadmill locomotion using biplanar radiography. Rats were euthanized 8 weeks after MMT or sham surgery, and the microstructure of the tibial cartilage and subchondral bone was quantified using contrast enhanced micro-CT. All three MMT groups showed signs of PTOA (full-thickness lesions and/or increased cartilage volume) compared to the sham group, however the regular and treadmill-running groups had greater osteophyte formation than the immobilization group. For the immobilization group, increased volume was only observed in the anterior region of the cartilage. The treadmill-running group demonstrated a greater knee varus angle at mid-stance than the sham group, while the immobilization group demonstrated greater reduction in voluntary running than all the other groups at 2 weeks post-surgery. Elevated weight-bearing via treadmill running at a slow/moderate speed did not accelerate PTOA in MMT rats when compared to regular weight-bearing. Reduced weight-bearing via immobilization may attenuate overall PTOA but still resulted in regional cartilage degeneration. Overall, there were minimal differences in hindlimb kinematics and voluntary running between MMT and sham rats.
Identifiants
pubmed: 31437580
pii: S1063-4584(19)31171-9
doi: 10.1016/j.joca.2019.08.001
pmc: PMC7576441
mid: NIHMS1636964
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1851-1859Subventions
Organisme : RRD VA
ID : I21 RX002372
Pays : United States
Informations de copyright
Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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