Staphylococcus aureus intra-mammary infection affects the expression pattern of IL-R8 in goat.
Animals
Down-Regulation
Epithelial Cells
/ immunology
Female
Goat Diseases
/ immunology
Goats
/ microbiology
Immunity, Innate
Inflammation
Mammary Glands, Animal
/ immunology
Mastitis
/ immunology
Receptors, Interleukin-8
/ blood
Staphylococcal Infections
/ immunology
Staphylococcus aureus
/ immunology
Up-Regulation
Goat
IL-1R8/TIR8/SIGIRR
Innate immunity
Intra-mammary infection
Staphylococcus aureus
Journal
Comparative immunology, microbiology and infectious diseases
ISSN: 1878-1667
Titre abrégé: Comp Immunol Microbiol Infect Dis
Pays: England
ID NLM: 7808924
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
11
12
2018
revised:
24
07
2019
accepted:
26
07
2019
pubmed:
23
8
2019
medline:
6
2
2020
entrez:
23
8
2019
Statut:
ppublish
Résumé
IL-1R8 is a member of Interleukin-1 receptor family acting as a negative regulator of inflammation reliant on ILRs and TLRs activation. IL-1R8 role has never been evaluated in acute bacterial mastitis. We first investigated IL-1R8 sequence conservation among different species and its pattern of expression in a wide panel of organs from healthy goats. Then, modulation of IL-1R8 during natural and experimental mammary infection was evaluated and compared in blood, milk and mammary tissues from healthy and Staphylococcus aureus infected goats. IL-1R8 has a highly conserved sequence among vertebrates. Goat IL-1R8 was ubiquitously expressed in epithelial and lymphoid tissues with highest levels in pancreas. IL-1R8 was down-regulated in epithelial mammary cells following S. aureus infection. Interestingly it was up-regulated in leukocytes infiltrating the infected mammary tissues suggesting that it could represent a target of S. aureus immune evasion.
Identifiants
pubmed: 31437679
pii: S0147-9571(19)30136-5
doi: 10.1016/j.cimid.2019.101339
pii:
doi:
Substances chimiques
Receptors, Interleukin-8
0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101339Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.