The Role of Anxiety Sensitivity and Expectancy Manipulation on Panic-Like Response to the 35% CO2 Challenge in Healthy Subjects.
Anxiety sensitivity
CO2 challenge
Instruction manipulation
Panic
Journal
Neuropsychobiology
ISSN: 1423-0224
Titre abrégé: Neuropsychobiology
Pays: Switzerland
ID NLM: 7512895
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
04
2019
accepted:
16
07
2019
pubmed:
23
8
2019
medline:
1
5
2020
entrez:
23
8
2019
Statut:
ppublish
Résumé
The 35% CO2 challenge is a well-established method triggering panic attacks under laboratory-controlled conditions. There is an ongoing debate whether single or the joined effects of the instructional set and anxiety sensitivity (AS) can alter the outcome of the challenge. The present study investigated the effects of instruction manipulation and AS on panic-like response to the 35% CO2 challenge. Eighty healthy subjects, with high or low levels of AS, were randomized into 4 groups based on standard/manipulated instructional sets as well as 35% CO2 mixture/room air inhalation. Subjects filled in the Visual Analogue Scale of Anxiety (VAAS), the Visual Analogue Scale of Fear (VAS-F), the VAS of Discomfort (VAS-D), and the Panic Symptom List (PSL). Blood pressure and heart rate were measured at pre- and posttest. Hierarchical multiple regression analyses showed greater psychological responses at VAAS, VAS-F, VAS-D, and PSL and higher systolic blood pressure under 35% CO2 challenge if compared to room air inhalation while instructional set and AS did not influence the response. The present study confirms that neither instructional test nor AS alter the outcome of the 35% CO2 challenge.
Sections du résumé
BACKGROUND
BACKGROUND
The 35% CO2 challenge is a well-established method triggering panic attacks under laboratory-controlled conditions. There is an ongoing debate whether single or the joined effects of the instructional set and anxiety sensitivity (AS) can alter the outcome of the challenge.
OBJECTIVES
OBJECTIVE
The present study investigated the effects of instruction manipulation and AS on panic-like response to the 35% CO2 challenge.
METHODS
METHODS
Eighty healthy subjects, with high or low levels of AS, were randomized into 4 groups based on standard/manipulated instructional sets as well as 35% CO2 mixture/room air inhalation. Subjects filled in the Visual Analogue Scale of Anxiety (VAAS), the Visual Analogue Scale of Fear (VAS-F), the VAS of Discomfort (VAS-D), and the Panic Symptom List (PSL). Blood pressure and heart rate were measured at pre- and posttest.
RESULTS
RESULTS
Hierarchical multiple regression analyses showed greater psychological responses at VAAS, VAS-F, VAS-D, and PSL and higher systolic blood pressure under 35% CO2 challenge if compared to room air inhalation while instructional set and AS did not influence the response.
CONCLUSIONS
CONCLUSIONS
The present study confirms that neither instructional test nor AS alter the outcome of the 35% CO2 challenge.
Identifiants
pubmed: 31437853
pii: 000502150
doi: 10.1159/000502150
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-217Informations de copyright
© 2019 S. Karger AG, Basel.