Glycoprotein YKL-40 Is Elevated and Predicts Disease Severity in Puumala Hantavirus Infection.
Acute Kidney Injury
/ pathology
Adult
Aged
Autoantigens
/ analysis
Biomarkers
/ blood
Chitinase-3-Like Protein 1
/ analysis
Creatinine
/ blood
Female
Hemorrhagic Fever with Renal Syndrome
/ pathology
Humans
Inflammation
/ virology
Interleukin-6
/ blood
Male
Middle Aged
Puumala virus
/ pathogenicity
Severity of Illness Index
CHI3L1
HFRS
Puumala virus
YKL-40
biomarker
hantavirus
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
21 08 2019
21 08 2019
Historique:
received:
03
07
2019
revised:
15
08
2019
accepted:
17
08
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
10
9
2020
Statut:
epublish
Résumé
Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic inflammation. In the present study, we examined plasma YKL-40 levels and the associations of YKL-40 with disease severity in acute PUUV infection. A total of 79 patients treated in Tampere University Hospital during 2005-2014 were studied. Plasma YKL-40 was measured in the acute phase, the recovery phase, and one year after hospitalization. Plasma YKL-40 levels were higher during the acute phase compared to the recovery phase and one year after hospitalization (median YKL-40 142 ng/mL, range 11-3320, vs. 45 ng/mL, range 15-529, vs. 32 ng/mL, range 3-213,
Identifiants
pubmed: 31438470
pii: v11090767
doi: 10.3390/v11090767
pmc: PMC6784349
pii:
doi:
Substances chimiques
Autoantigens
0
Biomarkers
0
CHI3L1 protein, human
0
Chitinase-3-Like Protein 1
0
Interleukin-6
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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