Relationship between gender and survival in a real-life cohort of patients with COPD.
Aged
Anxiety
/ epidemiology
Body Mass Index
Cohort Studies
Dyspnea
/ epidemiology
Female
Forced Expiratory Volume
France
/ epidemiology
Humans
Kaplan-Meier Estimate
Male
Malnutrition
/ complications
Middle Aged
Pulmonary Disease, Chronic Obstructive
/ epidemiology
Respiratory Function Tests
Sex Factors
Survival Analysis
Chronic obstructive pulmonary disease
Gender differences
Survival
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
22 Aug 2019
22 Aug 2019
Historique:
received:
16
02
2019
accepted:
05
08
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
8
2
2020
Statut:
epublish
Résumé
Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this translates into a different prognosis remains to be determined. Our aim was to assess whether the greater clinical impact of COPD in women was associated with differences in 3-year mortality rates. In the French Initiatives BPCO real-world cohort, 177 women were matched up to 458 menon age (within 5-year intervals) and FEV For a given age and level of airflow obstruction, women with COPD had more severe dyspnea, lower BMI, and were more likely to exhibit anxiety. Nevertheless, three-year mortality rate was comparable among men and women, respectively 11.2 and 10.8%. In a multivariate model, the only factors significantly associated with mortality were dyspnea and malnutrition but not gender. Although women with COPD experience higher levels of dyspnea and anxiety than men at comparable levels of age and FEV1, these differences do not translate into variations in 3-year mortality rates. 04-479.
Sections du résumé
BACKGROUND
BACKGROUND
Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this translates into a different prognosis remains to be determined. Our aim was to assess whether the greater clinical impact of COPD in women was associated with differences in 3-year mortality rates.
METHODS
METHODS
In the French Initiatives BPCO real-world cohort, 177 women were matched up to 458 menon age (within 5-year intervals) and FEV
RESULTS
RESULTS
For a given age and level of airflow obstruction, women with COPD had more severe dyspnea, lower BMI, and were more likely to exhibit anxiety. Nevertheless, three-year mortality rate was comparable among men and women, respectively 11.2 and 10.8%. In a multivariate model, the only factors significantly associated with mortality were dyspnea and malnutrition but not gender.
CONCLUSION
CONCLUSIONS
Although women with COPD experience higher levels of dyspnea and anxiety than men at comparable levels of age and FEV1, these differences do not translate into variations in 3-year mortality rates.
TRIAL REGISTRATION
BACKGROUND
04-479.
Identifiants
pubmed: 31439045
doi: 10.1186/s12931-019-1154-3
pii: 10.1186/s12931-019-1154-3
pmc: PMC6704674
doi:
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
191Subventions
Organisme : CSRD VA
ID : 1
Pays : United States
Investigateurs
P R Burgel
(PR)
G Deslee
(G)
P Surpas
(P)
O Le Rouzic
(O)
T Perez
(T)
N Roche
(N)
G Brinchault-Rabin
(G)
D Caillaud
(D)
P Chanez
(P)
I Court-Fortune
(I)
R Escamilla
(R)
G Jebrak
(G)
P Nesme-Meyer
(P)
M Zysman
(M)
C Pinet
(C)
Brigitte Risse
(B)
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