Can DCE-MRI reduce the number of PI-RADS v.2 false positive findings? Role of quantitative pharmacokinetic parameters in prostate lesions characterization.
Aged
Aged, 80 and over
Contrast Media
/ pharmacokinetics
Evaluation Studies as Topic
False Positive Reactions
Humans
Image Enhancement
/ methods
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Prostate
/ diagnostic imaging
Prostatic Neoplasms
/ diagnostic imaging
ROC Curve
Radiology Information Systems
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Diagnosis
Magnetic resonance imaging
Perfusion imaging
Prostatic neoplasms
Journal
European journal of radiology
ISSN: 1872-7727
Titre abrégé: Eur J Radiol
Pays: Ireland
ID NLM: 8106411
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
18
02
2019
revised:
16
06
2019
accepted:
01
07
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
31
12
2019
Statut:
ppublish
Résumé
To test the potential impact of pharmacokinetic parameters, derived from DCE-MRI analysis, on the diagnostic performance of PI-RADSv.2 classification in prostate lesions characterization. Among patients who underwent multiparametric prostate MRI (mpMRI) (January 2016-March 2018) followed by histological evaluation (targeted biopsies/prostatectomy), 103 men were retrospectively selected. For each patient the index lesion was identified and pharmacokinetic parameters (Ktrans, Kep, Ve, Vp) were assessed. MRI diagnostic performance in the detection of significant tumors [Gleason Score (GS)≥7] was assessed, considering PI-RADS≥3 as positive. GS ≥ 7 (n = 59) showed higher Ktrans (p < 0.01) and Kep (p = 0.01) compared to GS < 7. At ROC curve analysis, a Ktrans cut-off of 191 × 10 Despite its high sensitivity prostate mpMRI generates many false positive cases: Ktrans in addition to PIRADS v.2 seems to improve MRI-PPV and may help in avoiding redundant biopsies.
Identifiants
pubmed: 31439258
pii: S0720-048X(19)30235-9
doi: 10.1016/j.ejrad.2019.07.002
pii:
doi:
Substances chimiques
Contrast Media
0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-57Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.