Stat3 in osteocytes mediates osteogenic response to loading.
ATP
Bone formation
Mechanotransduction
Osteocyte
ROS
Signal transducers and activators of transcription 3 (Stat3)
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
09
07
2019
accepted:
26
07
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
24
8
2019
Statut:
epublish
Résumé
Signal transducer and activator of transcription 3 (Stat3) is a member of the Stat family of proteins involved in signaling in many different cell types, including osteocytes. Osteocytes are considered major mechanosensing cells in bone due to their intricate dendritic networks able to sense changes in physical force and to orchestrate the response of osteoclasts and osteoblasts. We examined the role of Stat3 in osteocytes by generating mice lacking Stat3 in these cells using the Dmp-1(8kb)-Cre promoter (Stat3cKO mice). Compared to age-matched littermate controls, Stat3cKO mice of either sex (18 weeks old) exhibit reduced bone formation indices, decreased osteoblasts and increased osteoclasts, and altered material properties, without detectable changes in bone mineral density (BMD) or content of either trabecular or cortical bone. In addition, Stat3cKO mice of either sex show significantly decreased load-induced bone formation. Furthermore, pharmacologic inhibition of Stat3 in osteocytes
Identifiants
pubmed: 31440530
doi: 10.1016/j.bonr.2019.100218
pii: S2352-1872(19)30024-5
pii: 100218
pmc: PMC6700265
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100218Subventions
Organisme : NINDS NIH HHS
ID : R01 NS098772
Pays : United States
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
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