Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis.
Atherosclerosis
Endothelial activation
Magnetic resonance imaging (MRI)
Mineralization
Positrons emission tomography (PET)
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
22 Aug 2019
22 Aug 2019
Historique:
received:
11
06
2019
accepted:
09
08
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
24
8
2019
Statut:
epublish
Résumé
Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce. A group of uremic ApoE Ur mice showed an active and sustained mineralization process compared to Ctl mice (p = 0.002) using [18F]NaF PET imaging. Calcium plasma level was increased in Ur (2.54 ± 0.09 mM, n = 17) compared to NUr and Ctl mice (2.24 ± 0.01, n = 22, and 2.14 ± 0.02, n = 27, respectively; p < 0.0001). Likewise, vascular calcium content was increased in Ur (0.51 ± 0.06 μg Ca Preclinical molecular imaging allowed in vivo characterization of the early phase of atherosclerosis. [18F]NaF PET showed early and sustained vascular mineralization in uremic ApoE
Identifiants
pubmed: 31440854
doi: 10.1186/s13550-019-0550-5
pii: 10.1186/s13550-019-0550-5
pmc: PMC6706501
doi:
Types de publication
Journal Article
Langues
eng
Pagination
80Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-16-RHUS-0003
Références
Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):1998-2003
pubmed: 11742876
Gene. 2002 Jan 9;282(1-2):1-17
pubmed: 11814673
J Am Soc Nephrol. 2004 Jun;15(6):1495-503
pubmed: 15153560
J Am Soc Nephrol. 2005 Jan;16(1):109-16
pubmed: 15563564
Circulation. 2006 Oct 3;114(14):1504-11
pubmed: 17000904
Circ Res. 2006 Nov 10;99(10):1044-59
pubmed: 17095733
Circulation. 2007 Jan 23;115(3):377-86
pubmed: 17224478
Biomaterials. 2008 Sep;29(26):3583-90
pubmed: 18533252
Eur J Nucl Med Mol Imaging. 2009 Jun;36(6):979-85
pubmed: 19183999
J Nucl Med. 2010 Jun;51(6):862-5
pubmed: 20484438
J Nephrol. 2011 May-Jun;24 Suppl 18:S11-5
pubmed: 21623577
Hell J Nucl Med. 2011 May-Aug;14(2):114-20
pubmed: 21761011
Stroke. 2013 Jul;44(7):1988-96
pubmed: 23743972
Theranostics. 2013 May 25;3(6):428-36
pubmed: 23781289
J Ultrasound Med. 2014 Nov;33(11):1941-8
pubmed: 25336481
Front Cell Neurosci. 2014 Nov 27;8:389
pubmed: 25505871
J Nucl Med. 2015 Jul;56(7):1019-23
pubmed: 25952737
Calcif Tissue Int. 2015 Aug;97(2):179-92
pubmed: 26087714
Nat Commun. 2015 Jul 07;6:7495
pubmed: 26151378
Theranostics. 2015 Aug 08;5(11):1187-202
pubmed: 26379785
Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):249-258
pubmed: 27796543
Mol Imaging Biol. 2018 Dec;20(6):984-992
pubmed: 29713959
Mol Imaging Biol. 2018 Dec;20(6):869-887
pubmed: 30250990
Urol Res. 1988;16(2):119-26
pubmed: 3369000
Circulation. 1995 Oct 15;92(8):2029-32
pubmed: 7554176
Arterioscler Thromb. 1994 Jan;14(1):133-40
pubmed: 8274468