Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene-environment interactions.
5-Hydroxyl tryptamine transporter gene-linked polymorphic region
Children and adolescents
Disaster
Post-traumatic stress disorder
Symptom course
Journal
International journal of psychology : Journal international de psychologie
ISSN: 1464-066X
Titre abrégé: Int J Psychol
Pays: England
ID NLM: 0107305
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
23
10
2018
accepted:
05
08
2019
pubmed:
24
8
2019
medline:
27
2
2021
entrez:
24
8
2019
Statut:
ppublish
Résumé
Experiencing disasters causes severe mental disorders, among which post-traumatic stress disorder (PTSD) is the most common. We conducted a longitudinal study to examine the effect of 5-hydroxyl tryptamine transporter gene-linked polymorphic region (5-HTTLPR) genotype on child and adolescent PTSD symptom course after the 2008 Wenchuan Earthquake. We genotyped 963 participants who personally experienced the earthquake. PTSD symptoms were measured by University of California, Los Angeles PTSD reaction index at 2.5, 3.5, 4.5 and 5.5 years after the earthquake, respectively. Latent growth model was utilised to examine the main effect and gene-environment interaction effect of 5-HTTLPR on PTSD's symptom course. 5-HTTLPR genotype predicted initial PTSD symptom severity (β = 0.108, p = .019) and rates of symptom recovery (β = -0.120, p = .031) between 2.5 and 5.5 years. Compared with L' allele carriers, those with S'S' genotype showed higher initial symptom severity but also faster recovery rate. 5-HTTLPR genotype only predicted symptom severity at 2.5 years after the earthquake, after controlling for sex, age, ethnicity and trauma severity (β = 0.108, p = .019). This is the first evidence of the effect of 5-HTTLPR genotype on child and adolescent PTSD symptoms longitudinally, offering a novel perspective on the effect of 5-HTTLPR on PTSD symptom development following trauma exposure.
Substances chimiques
SLC6A4 protein, human
0
Serotonin Plasma Membrane Transport Proteins
0
Types de publication
Historical Article
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22-29Subventions
Organisme : Beijing Municipal Science and Technology Commission
ID : Z171100000117014
Organisme : External Cooperation Program of Chinese Academy of Sciences
ID : 153111KYSB20160036
Organisme : Key Project of Research Base of Humanities and Social Sciences of Ministry of Education
ID : 16JJD190006
Organisme : Key Research Program of the Chinese Academy of Sciences
ID : ZDRW-XH-2019-4
Organisme : National Natural Science Foundation of China
ID : 31271099
Organisme : National Natural Science Foundation of China
ID : 31471004
Informations de copyright
© 2019 International Union of Psychological Science.
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