Novel therapeutic interventions in cancer treatment using protein and peptide-based targeted smart systems.
Cancer
Cellular immunology
Nanomedicines
Peptides
Protein
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
07
07
2019
revised:
19
08
2019
accepted:
20
08
2019
pubmed:
24
8
2019
medline:
4
3
2022
entrez:
24
8
2019
Statut:
ppublish
Résumé
Cancer, being the most prevalent and resistant disease afflicting any gender, age or social status, is the ultimate challenge for the scientific community. The new generation therapeutics for cancer management has shifted the approach to personalized/precision medicine, making use of patient- and tumor-specific markers for specifying the targeted therapies for each patient. Peptides targeting these cancer-specific signatures hold enormous potential for cancer therapy and diagnosis. The rapid advancements in the combinatorial peptide libraries served as an impetus to the development of multifunctional peptide-based materials for targeted cancer therapy. The present review outlines benefits and shortcomings of peptides as cancer therapeutics and the potential of peptide modified nanomedicines for targeted delivery of anticancer agents.
Identifiants
pubmed: 31442570
pii: S1044-579X(19)30160-9
doi: 10.1016/j.semcancer.2019.08.023
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Peptide Fragments
0
Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-267Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.