Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription.

Animals Disease Susceptibility Epigenesis, Genetic Gene Expression Regulation Hepatic Stellate Cells / metabolism Liver Cirrhosis / etiology Mice Mice, Transgenic Models, Biological NADPH Oxidases / genetics Reactive Oxygen Species / metabolism Serum Response Factor / genetics Transcriptional Activation
Hepatic stellate cell Liver fibrosis Neutrophil cytosolic factor Reactive oxygen species Serum response factor Transcriptional regulation

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
09 2019
Historique:
received: 03 07 2019
revised: 13 08 2019
accepted: 15 08 2019
pubmed: 24 8 2019
medline: 28 2 2020
entrez: 24 8 2019
Statut: ppublish

Résumé

Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation of reactive oxygen species (ROS) serves as a driving force for HSC activation. The regulatory subunits of the NOX complex, NCF1 (p47

Identifiants

DOI: 10.1016/j.redox.2019.101302 PMID: 31442911 PMC: PMC6831835
pubmed: 31442911
pii: S2213-2317(19)30757-8
doi: 10.1016/j.redox.2019.101302
pmc: PMC6831835
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
Serum Response Factor 0
NADPH Oxidases EC 1.6.3.-
Ncf2 protein, mouse EC 1.6.3.1
neutrophil cytosolic factor 1 EC 1.6.3.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101302

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

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Auteurs

Ming Kong (M)

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.

Xuyang Chen (X)

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.

Fangqiao Lv (F)

Department of Cell Biology and the Municipal Laboratory of Liver Protection and Regulation of Regeneration, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Haozhen Ren (H)

Department of Hepato-biliary Surgery and Department of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Zhiwen Fan (Z)

Department of Hepato-biliary Surgery and Department of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Hao Qin (H)

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.

Liming Yu (L)

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.

Xiaolei Shi (X)

Department of Hepato-biliary Surgery and Department of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: njsxl2000@163.com.

Yong Xu (Y)

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China; Institute of Biomedical Research, Liaocheng University, Liaocheng, China. Electronic address: yjxu@njmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines à domaine MADS › Facteur de réponse au sérum › Serum response factor (SRF) promotes ROS...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Serum response factor (SRF) promotes ROS...