Impaired metabolic and hepatic functions following subcutaneous lipectomy in adult obese rats.
Adiponectin
/ metabolism
Adipose Tissue
/ metabolism
Animals
Blood Glucose
/ metabolism
Body Mass Index
Body Weight
/ physiology
Disease Models, Animal
Fasting
/ metabolism
Female
Insulin
/ metabolism
Insulin Resistance
/ physiology
Leptin
/ metabolism
Lipectomy
/ methods
Liver
/ metabolism
Malondialdehyde
/ metabolism
Obesity
/ metabolism
Rats
dyslipidaemia
hepatic functions
obesity
ovariectomy
subcutaneous lipectomy
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
21
02
2019
accepted:
16
08
2019
pubmed:
24
8
2019
medline:
11
8
2020
entrez:
24
8
2019
Statut:
ppublish
Résumé
What is the central question of this study? What is the impact and drawbacks of subcutaneous lipectomy on body metabolism? What is the main finding and its importance? Subcutaneous lipectomy resulted in deterioration of hepatic functions, atherosclerotic lipid profile and disturbed redox state. While the results support lipectomy as an effective treatment for obesity, lipectomy induces unfavourable changes in health. The number of obese older adults is on the rise, but data about proper treatment of obesity in the elderly is controversial. The present study was designed to investigate the effectiveness and consequences of partial subcutaneous lipectomy, as a rapid medical intervention against increased accumulation of body fat, in adult obese rats. The study was conducted on adult (9-12 months) female rats, in which obesity was induced by bilateral surgical ovariectomy. They were randomized into two main groups: short term (5 weeks) and long term (10 weeks). Both groups were subdivided into control, ovariectomized (OVX) and ovariectomized lipectomized groups. Body weight (BW) was measured and body mass index (BMI) calculated. Fasting blood glucose, lipid profile and plasma levels of total proteins, albumin, liver enzymes, malondialdehyde (MDA), leptin and adiponectin were determined. The content of both blood and hepatic tissue of reduced glutathione was estimated. In addition, histological study of the liver, aorta and peri-renal fat was performed. Compared to controls, OVX rats showed significant increase in BW, BMI and plasma levels of liver enzymes, MDA and leptin. Histological study revealed vacuolated ballooned hepatocytes and enlarged irregular visceral adipocytes with atherosclerotic changes in the wall of aorta. Following subcutaneous lipectomy, rats exhibited significant fasting hyperglycaemia, dyslipidaemia, lowered plasma albumin and disturbed redox state with aggravation of the histological changes. The findings indicate that although subcutaneous lipectomy appears to be effective in combating obesity in older females, it has unfavourable effects on both metabolic and hepatic functions.
Substances chimiques
Adiponectin
0
Blood Glucose
0
Insulin
0
Leptin
0
Malondialdehyde
4Y8F71G49Q
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1661-1677Informations de copyright
© 2019 The Authors. Experimental Physiology © 2019 The Physiological Society.
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