Chronic Hepatitis E Virus Infection during Lymphoplasmacytic Lymphoma and Ibrutinib Treatment.
Bruton’s tyrosine kinase
chronification
hepatitis E virus
ibrutinib
immunosuppression
lymphoplasmacytic lymphoma
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
22 Aug 2019
22 Aug 2019
Historique:
received:
18
07
2019
revised:
16
08
2019
accepted:
17
08
2019
entrez:
25
8
2019
pubmed:
25
8
2019
medline:
25
8
2019
Statut:
epublish
Résumé
Hepatitis E virus (HEV) is an increasingly recognised pathogen, affecting several hundred thousand individuals in western countries each year. Importantly, the majority of immunocompromised individuals are not able to clear HEV but develop a chronic course of infection. In the case of lymphoma, which is an inherent immunosuppressive disease per se, chemotherapy can even further exacerbate the immunosuppressive status. As the mechanism of HEV chronification is barely understood, it is important to gain knowledge about the influence of chemotherapeutic drugs on the HEV replication cycle to guide rational clinical management of HEV infection in such patients. In this case report, a 70 year old man was diagnosed with lymphoplasmacytic lymphoma. As we observed the occurrence of chronic HEV after treatment with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib
Identifiants
pubmed: 31443360
pii: pathogens8030129
doi: 10.3390/pathogens8030129
pmc: PMC6789582
pii:
doi:
Types de publication
Case Reports
Langues
eng
Subventions
Organisme : This work was supported by a grant from the German Federal Ministry of Health with regard to a decision of the German Bundestag by the Federal Government
ID : CHED-project grant No: ZMVI1-2516-AUK-701 /BMG: 321-4471-02/157
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