A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

Cre/loxP bacterial artificial chromosome embryonic stem cells gene targeting liver steatosis recombineering

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
22 Aug 2019
Historique:
received: 06 08 2019
accepted: 16 08 2019
entrez: 25 8 2019
pubmed: 25 8 2019
medline: 25 8 2019
Statut: epublish

Résumé

Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors.

Identifiants

pubmed: 31443474
pii: cancers11091226
doi: 10.3390/cancers11091226
pmc: PMC6770775
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Austrian Science Fund
ID : P29222
Organisme : Austrian Science Fund
ID : P 25599
Organisme : Austrian Science Fund FWF
ID : P 25599
Pays : Austria
Organisme : Austrian Science Fund
ID : P25925
Organisme : Austrian Science Fund
ID : P26908

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Auteurs

Herwig P Moll (HP)

Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.

Julian Mohrherr (J)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.

Leander Blaas (L)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Novum, 14183 Huddinge, Sweden.

Monica Musteanu (M)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
CNIO (Spanish National Cancer Research Centre), E-28029 Madrid, Spain.

Patricia Stiedl (P)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.

Beatrice Grabner (B)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.

Katalin Zboray (K)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, 2462 Martonvásár, Hungary.

Margit König (M)

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria.

Dagmar Stoiber (D)

Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Department of Pharmacology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.

Thomas Rülicke (T)

Institute of Laboratory Animal, Science, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

Sabine Strehl (S)

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria.

Robert Eferl (R)

Institute of Cancer Research, Medical University Vienna & Comprehensive Cancer Center (CCC), 1090 Vienna, Austria.

Emilio Casanova (E)

Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria. emilio.casanova@meduniwien.ac.at.
Ludwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria. emilio.casanova@meduniwien.ac.at.

Classifications MeSH