TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage.
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Blastocyst
/ cytology
Cell Cycle Proteins
/ genetics
DNA-Binding Proteins
/ genetics
Ectopic Gene Expression
Embryo, Mammalian
/ metabolism
Embryonic Stem Cells
/ metabolism
Female
Gene Expression Regulation, Developmental
Male
Mice
/ embryology
Mice, Transgenic
Muscle Proteins
/ genetics
Pluripotent Stem Cells
/ metabolism
Protein Serine-Threonine Kinases
/ metabolism
SOXB1 Transcription Factors
/ genetics
TEA Domain Transcription Factors
Trans-Activators
/ genetics
Transcription Factors
/ genetics
Tumor Suppressor Proteins
/ metabolism
YAP-Signaling Proteins
HIPPO signaling
Preimplantation
Stem cell progenitors
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
06 09 2019
06 09 2019
Historique:
received:
25
04
2019
accepted:
09
08
2019
pubmed:
25
8
2019
medline:
14
7
2020
entrez:
25
8
2019
Statut:
epublish
Résumé
In mice, pluripotent cells are thought to derive from cells buried inside the embryo around the 16-cell stage.
Identifiants
pubmed: 31444221
pii: dev.179861
doi: 10.1242/dev.179861
pmc: PMC6765126
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Cell Cycle Proteins
0
DNA-Binding Proteins
0
Muscle Proteins
0
SOXB1 Transcription Factors
0
Sox2 protein, mouse
0
TEA Domain Transcription Factors
0
Tead4 protein, mouse
0
Trans-Activators
0
Transcription Factors
0
Tumor Suppressor Proteins
0
Wwtr1 protein, mouse
0
YAP-Signaling Proteins
0
Yap1 protein, mouse
0
LATS2 protein, mouse
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM104009
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131759
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD087166
Pays : United States
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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