A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
23 08 2019
23 08 2019
Historique:
received:
30
04
2019
accepted:
15
07
2019
entrez:
25
8
2019
pubmed:
25
8
2019
medline:
27
5
2020
Statut:
ppublish
Résumé
A dense population of embryo-derived Langerhans cells (eLCs) is maintained within the sealed epidermis without contribution from circulating cells. When this network is perturbed by transient exposure to ultraviolet light, short-term LCs are temporarily reconstituted from an initial wave of monocytes but thought to be superseded by more permanent repopulation with undefined LC precursors. However, the extent to which this process is relevant to immunopathological processes that damage LC population integrity is not known. Using a model of allogeneic hematopoietic stem cell transplantation, where alloreactive T cells directly target eLCs, we have asked whether and how the original LC network is ultimately restored. We find that donor monocytes, but not dendritic cells, are the precursors of long-term LCs in this context. Destruction of eLCs leads to recruitment of a wave of monocytes that engraft in the epidermis and undergo a sequential pathway of differentiation via transcriptionally distinct EpCAM
Identifiants
pubmed: 31444235
pii: 4/38/eaax8704
doi: 10.1126/sciimmunol.aax8704
pmc: PMC6894529
mid: NIHMS1056069
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI093870
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L001608/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : 1450227
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100156
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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